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anti-Human REV3L Antibodies:
anti-Rat (Rattus) REV3L Antibodies:
anti-Mouse (Murine) REV3L Antibodies:
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Human Polyclonal REV3L Primary Antibody for ELISA, WB - ABIN562630
Zhang, Chen, Zhao, Cao, Tong, Lu, Wu, Shen, Wei, Lu: REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. in Oncogene 2013
Show all 2 Pubmed References
We have identified and characterised a novel DNA damage response mechanism in melanoma. Instead of increasing levels of RAD51 on encountering cisplatin-induced interstrand crosslinks during replication, melanoma cells shut down RAD51 synthesis and instead boost levels of translesion synthesis DNA polymerase zeta to allow replication to proceed
Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L
These results demonstrate a previously unrecognized relationship between p53 and REV3L in cancer cell metabolism and may lead to improvements in chemotherapy treatment plans that reduce cisplatin resistance in lung cancer.
REV3/ATR knockdown enhances the cytotoxicity of cisplatin in non-small cell lung cells.
The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase.
The results indicate that human DNA polymerase zeta plays important roles in induction of mutations, clastogenicity and in cellular survival of the damaged human cells.
loss-of-function of REV3L dramatically enhanced the sensitivity of SCCHN cells to dacomitinib by the loss of both translesion synthesis and homologous recombination pathways.
REV3L plays an important role in esophageal squamous cell carcinoma (ESCC) progression and chemoresistance, and is a potential diagnostic marker and therapeutic target for ESCC
REV3 functions in mammalian mitochondria and that mitochondrial REV3 is associated with the tumorigenic potential of cells.
Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment
A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta
results can be unified by a model in which slowly dividing cells accumulate replication-associated DNA breaks but otherwise survive Rev3L deletion, but functional polzeta is essential for responses requiring rapid proliferation
Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa (show POLL Antibodies)
DNA polymerase zeta generates tandem mutations in immunoglobulin variable regions
Pol zeta was determined to be necessary for proliferation of normal cells using conditions in which Rev3L could be conditionally inactivated by Cre recombinase (show RAG1 Antibodies).
REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus.
In the presence of reduced levels of Rev3, an essential component of Polzeta, tumors exhibited pronounced sensitivity to cisplatin, leading to a significant extension in overall survival of treated recipient mice.
found that Rev3 is important for a post-replication repair pathway of helix-distorting [6-4]pyrimidine-pyrimidone photoproducts
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.
DNA polymerase zeta catalytic subunit
, Rev-3, yeast, homolog-like (polymerase, DNA, zeta)
, REV3-like, catalytic subunit of DNA polymerase zeta
, REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
, DNA polymerase zeta
, DNA polymerase zeta catalytic subunit-like
, Protein reversionless 3-like
, REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like
, Seizure-related protein 4
, seizure-related protein 4