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Human Polyclonal XRCC1 Primary Antibody for ICC, IF - ABIN151964
Iles, Rulten, El-Khamisy, Caldecott: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. in Molecular and cellular biology 2007
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our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1), apoptosis genes (TP53 (show TP53 Antibodies)), as well as of apoptosis inhibition genes (MDM2 (show MDM2 Antibodies)).
Meta-analysis: in Non-Small-Cell Lung Carcinoma patients treated with platinum-based regimen, XRCC1 194Arg allele suggest poor objective response rate, the GlnGln genotype of XRCC1 399 suggest poorer overall survival in Caucasian patients, and longer PFS in Asian patients.
Our meta-analysis suggested that Arg399Gln in XRCC1 was associated with endometriosis risk. And especially in Asians, the A allele might be a preventive factor for this disease.
Our results showed that DNA base excision repair proteins APE-1 (show APEX1 Antibodies) and XRCC-1 are overexpressed in tongue squamous cell carcinoma and that XRCC-1 is associated with better clinical staging and nodal status.
The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.
DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1 (show GSTP1 Antibodies), RAD51 (show RAD51 Antibodies), XRCC1 and XRCC3 (show XRCC3 Antibodies) genes in BC patients and the control group. Two variants in the 5'-UTR (show UTS2R Antibodies) of the XRCC3 (show XRCC3 Antibodies) and RAD51 (show RAD51 Antibodies) genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 (show XRCC3 Antibodies) gene.
The SNPs in CYP1A1 (show CYP1A1 Antibodies), GSTP1 (show GSTP1 Antibodies) and XRCC1 genes did not show significant association with complete remission (CR) rate, overall survival (OS) or event free survival (EFS (show EFS Antibodies)). However, XRCC1 Arg194Trp SNP was associated with higher drug toxicity; carriers of variant genotypes (CT and TT) had a significantly higher frequency of myelosuppression compared to those with the wild CC genotype
TGFB1 T10C and XRCC1 G399A SNPs were associated with CC risk in univariate and multivariate analysis and displayed allele-dosage effects and coselection in cancer patients. Patients harboring the majority allele TGFB1 T10 (Leu) or the variant allele XRCC1 399A (Gln) have approximately 1.5-fold increased risk to develop CC.
HOGG1 Ser326Cys, APE1 (show APEX1 Antibodies) Asp148Glu and XRCC1 Arg399Gln polymorphisms are correlated with the risk and clinicopathological features of PACG.
The current meta-analysis indicated that the XRCC1 Arg399Gln polymorphism decreased the risk of cervical cancer, while the Arg194Trp and Arg280His polymorphisms were not associated with cervical caner risk. [meta-anlalysis]
this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress
Repair independent of the well documented XRCC1-PNKP (show PNKP Antibodies) interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP (show PNKP Antibodies) binding.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (show PARP1 Antibodies) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (show ALDH1A2 Antibodies)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Antibodies), Neil1 (show NEIL1 Antibodies), Mutyh (show MUTYH Antibodies) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (show AFG3L2 Antibodies) serves to recruit XRCC1 that in turn binds and recruits pol beta (show POLB Antibodies), the primary DNA polymerase (show POLB Antibodies) of the base excision repair pathway.
Lig4 (show LIG4 Antibodies) and XRCC1 double-deficient cells switch as efficiently as Lig4 (show LIG4 Antibodies)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (show LIG1 Antibodies)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein