Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human SOX2 Protein expressed in HEK-293 Cells - ABIN2732450
Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. in Cell 2015
studies on the role of SOX2 in breast cancer may provide effective biomarkers and potential therapeutic targets for the diagnosis and treatment of breast cancer
In conclusion, targeted sequencing for SOX2 and VSX2 (show VSX2 Proteins) identified the etiology in two patients (7.4%) and this is the first report of SOX2 mutation from Egypt.
Kat2b (show KAT2B Proteins) are essential to the differentiation through enhancing recruitment neuroectodermal factors Sox2 and Pax6 (show PAX6 Proteins) to their target sites.
combined administration of small-interfering RNA (siRNA) transfection with PPARgamma (show PPARG Proteins) ligands induced downregulation of SOX2 and MMP2 (show MMP2 Proteins) activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) cleavage. Taken together, our findings suggest that a combination therapy using PPARgamma (show PPARG Proteins) ligands and its inhibitor could be a potential therapeutic strategy targeting glioblastom...
DDX53 (show DDX53 Proteins) directly regulates the SOX-2 expression in drug-resistant melanoma cells.
Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue.
Thus, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a functional organ.
Results provide evidence that SOX2 expression is regulated by the transcription factor HSF1 (show HSF1 Proteins).
SOX2 overexpression and the loss of Rb1 (show RB1 Proteins) protein expression might have a pivotal role in the divergent differentiation of pluripotent embryonic-like epithelial cells and the development of esophageal small-cell carcinoma.
In SOX2-deficient cells, BMP signaling is inhibited, but NODAL signaling is not activated. Thus, SOX2 appears to be downstream of BMP signaling but upstream of NODAL activation.
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 Proteins) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 Proteins) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 Proteins) and Sox2 proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 Proteins) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Proteins).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
The results revealed that the synthesized complex decoy can concomitantly target Sox2 and Oct4 (show POU5F1 Proteins), which subsequently represses the stemness properties of mESCs compared to controls through decreasing cell viability, arresting cell cycle in G0 /G1 phases, inducing apoptosis, and modulating differentiation in mESCs despite the presence of 2i/LIF (show LIF Proteins) in cell culture.
Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 (show HES5 Proteins) and for subsequent differentiation of the neuronal lineage.
Deletion of Sox2 specifically in Sox2(+) cells during incisor renewal revealed cellular plasticity that leads to the relatively rapid restoration of a Sox2-expressing cell population.
Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog (show NANOG Proteins), Oct4 (show POU5F1 Proteins), and Sox2.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4 (show POU5F1 Proteins), c-Myc (show MYC Proteins), Sox2 and Klf4 (show KLF4 Proteins).
By inhibiting NFATc2 (show NFAT1 Proteins) or calcineurin, induced pluripotent stem cells could be established without exogenous Sox2.
Folate receptor alpha (show FOLR1 Proteins) upregulates Oct4 (show POU5F1 Proteins), Sox2 and Klf4 (show KLF4 Proteins) and downregulates miR (show MLXIP Proteins)-138 and miR (show MLXIP Proteins)-let-7 in cranial neural crest cells.
Tbx6 (show TBX6 Proteins) and Sox2 co-expression marks a new transient progenitor state of the neuromesoderm lineage. Tbx6 (show TBX6 Proteins) and Sox2 co-expression marks neuromesoderm progenitors in the tail bud.
Stem cell and mesenchymal markers, including sex-determining region Y-box 2 (Sox2), are upregulated in aortic ECs of fat-fed ApoE (show APOE Proteins)(-/-) mice, which suggests that endothelial-mesenchymal transitions (EndMTs) contribute to atherosclerotic lesion calcification
miR (show MLXIP Proteins)-145 modulation of Sox2-Lin28 (show LIN28A Proteins)/let-7 network is crucial for neurogenesis progression.
these findings show that sox2 and sox3 (show SOX3 Proteins) are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency.
these data show that sox2 and sox3 (show SOX3 Proteins) exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 (show FGF8 Proteins) also modify sox2/3 functions.
Findings indicate a pivotal role for ZNF32 (show ZNF32 Proteins) function in SOX2 expression and regeneration regulation.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2
, SRY (sex determining region Y)-box 2
, transcription factor Sox-2
, sex-determining region Y-box 2
, Sox2 transcription factor
, delta EF2a
, LOW QUALITY PROTEIN: transcription factor SOX-2