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Data show in fragile X mental retardation syndrome 1 protein (Fmr1) knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity to neuronal stimulation.
data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain.
Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety.
Following ethanol administration, phosphorylation of TrkB is significantly increased in the striatum of Adcyl1 and Adcyl6 knock-out mice.
Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1, which defines a new signaling pathway employed by alpha7 nAChRs
Results indicate that thalamic AC1 plays a major role in patterning and refinement of the mouse thalamocortical circuitry
Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing.
Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor-adenylyl cyclase (AC) axis.
Contrast sensitivity is similarly reduced in Adcy1-/- mice.
These results suggest that AC1 in retinal ganglion cell axons mediates the development of retinotopy and eye-specific segregation in the superior colliculus and dorsal lateral geniculate nucleus.
The lower cAMP and AC mRNA level in hippocampus might participate in the molecular pathogenesis of ischemia/ reperfusion.
Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 from transcript to enzyme activity.
we have identified Adcy1 as a novel podocyte signaling protein that seems to have a role in compensatory physiological processes in the glomerulus.
These results suggest a function of adenylate cyclase 1 in the formation of peripheral nerve trajectories such as branching and pruning
AC1 has an essential role in fine patterning of the retinal map; retinal fibers from the ipsilateral and contralateral eye fail to segregate into eye-specific domains in the lateral geniculate nucleus and superior colliculus in AC1 mutant barrelless mice
The potential role of AC1 in mediating synaptic plasticity and regulating AMPAR trafficking during barrel map development is studied using barrelless mice, mutants without AC1 activity or cortical 'barrel' maps.
AC1 gene expression begins early in embryonic life (before E13), and its expression is much more widespread than in adults.
A presynaptic, cell autonomous role of AC1 is demonstrated in the retina; AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during refinement of the retinotopic map.
AC1 plays an important role in neuronal excitotoxicity
Data show that the adenylate cyclase (AC) pathway as genes relating to the antitumor activity of xanthohumol (XN) against tumor cells, and the pathway regulates various cellular functions via activating protein kinase A (PKA)-dependent phosphorylation.
Maps to 7p14.1-q11.22 between D7S2209 and marker D7S2435, maximum Lod score 5 for D7S1818.
STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition.
AC1 catalytic activity can be adjusted by mediating calmodulin activation of AC1 by reversible methionine oxidation in calmodulin.
Increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition.
AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2.
Compartmentalized AC1-CFTR association is responsible for Ca(2+)/cAMP cross-talk.
Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation.
Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory.
Expression of sensitization of AC1 involves Galpha(s)-adenylyl cyclase interactions.
These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking.
Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction.
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more persistent remote contextual memory.
This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.
brain adenylate cyclase 1
, adenylate cyclase 1 (brain)
, adenylate cyclase type 1-like
, ATP pyrophosphate-lyase 1
, Ca(2+)/calmodulin-activated adenylyl cyclase
, adenylate cyclase type 1
, adenylate cyclase type I
, adenylyl cyclase 1
, 3',5'-cyclic AMP synthetase
, adenyl cyclase
, ca(2+)/calmodulin-activated adenylyl cyclase