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In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops.
The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene.
Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism.
endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3
Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons.
This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder.
Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population.
expression of nodular ADCY6 (show ADCY6 Proteins), but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules
Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade.
Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction.
Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice.
AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE.
Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse.
increased Adcy3 activity robustly protect animals from diet-induced metabolic derangements
Study identifies the transient expression of histone demethylase (show MBD2 Proteins) LSD1 (show KDM1A Proteins) and the OR-dependent expression of adenylyl cyclase 3 as requirements for initiation and stabilization of OR expression.
Coexpression of serotonin receptor (show HTR1B Proteins) 5HT6 (show HTR6 Proteins) with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth.
Data suggest that while ADCY3 is responsible for a share of the cAMP in osteoclasts, the reduction of cAMP levels in the absence of this gene is insufficient to augment differentiation or effect changes in bone mass in vivo.
We conclude that AC3 in the main olfactory epithelium is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing.
In primary culture and in situ in G93A SOD1 (show SOD1 Proteins) mice there is a large reduction in the proportion of motor neurons bearing a primary cilium.
Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3.
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.
adenylate cyclase 8 (brain)
, adenylate cyclase type 3
, adenylate cyclase 3-like
, adenylate cyclase 3
, ATP pyrophosphate-lyase 3
, adenylate cyclase type III
, adenylate cyclase, olfactive type
, adenylyl cyclase 3
, adenylyl cyclase, type III
, type III adenylyl cyclase