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This study demonstrated a cell-autonomous requirement for ADCY8 in retinal neurons for normal midline crossing. These findings are the first to show that ADCY8 is required for axonal pathfinding before axons reach their targets.
Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety.
Dysregulation of a survival pathway in adenylyl cyclase 1 and 8 knockout mice was identified following early-life ethanol exposure.
Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy
ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion.
these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses.
ACVIII gene is regulated by CREB in vitro and in vivo and this regulation may contribute to CREB-dependent neural plasticity
AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2+-stimulated adenylyl cyclases are required for mossy fiber LTP
AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord.
AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1/CA2 region by adulthood. in the presynaptic active zone and extrasynaptic fractions.
data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome
Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women
Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion.
ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory.
Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression.
The adenylate cyclase 8 plays a major role in cAMP production.
Orai1 and AC8 binding mediates dynamic interplay between Ca2+ and cAMP signaling
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R.
Ca2+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.
Data reveal that an association of the Ca(2+)-stimulable AC8 with AKAP79/150 that limits the sensitivity of AC8 to intracellular Ca(2+) events.
The data of this study suggested that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder.
Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice expressing human adenylyl cyclase type 8.
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A was shown
recruited CaM is used by the C terminus of AC8 to mediate Ca2+ stimulation
Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction.
Redundant cyclase activity maintains the balance between presynaptically silent and active synapses, but AC8 plays an mportant role in resetting the balance of active to silent synapses after adaptation to strong activity.
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
Colocalizes with Orai1 and stromal interaction molecule 1 (STIM1) at the plasma membrane in lipid rafts
CaM is collapsed around the adenylyl cyclase 8 peptides that binds to CaM in an antiparallel orientation.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
adenylate cyclase 8 (brain)
, adenylate cyclase type VIII
, adenylate cyclase type 8
, adenylate cyclase type 8-like
, ATP pyrophosphate-lyase 8
, adenylyl cyclase 8
, ca(2+)/calmodulin-activated adenylyl cyclase
, adenylyl cyclase-8, brain
, type VIII adenylyl cyclase
, adenylate cyclase 3