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Human Polyclonal ADCY9 Primary Antibody for CM, ICC - ABIN2746180
Kolachala, Asamoah, Wang, Srinivasan, Merlin, Sitaraman: Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase. in The Journal of biological chemistry 2005
ADCY9 immunoreactivity score was significantly higher (P=0.002) in tumor tissues (6.40+/-1.26, n=200) than in adjacent normal samples (4.13+/-0.83, n=8). The IRS and mRNA expression of ADCY9 were correlated to colon cancer TNM staging.
polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers
The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9.
The effects of dalcetrapib on atherosclerotic outcomes are determined by correlated polymorphisms in the ADCY9 gene.
The importance of miR-181a-mediated AC9 downregulation in acute promyelocytic leukemia, is reported.
Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR-181b.
in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
The HIV-1 regulatory protein Tat was shown to inhibit the activity of adenylyl cyclase in rat microglial cells.
A case-control study using Ile772Met and a repeat (TTTA)n showed no significant association with mood disorders in Japan.
associated with bipolar disorder using pedigree linkage disequilibrium
blocking glycosylation of AC9 significantly attenuates Galpha(s) stimulation.
Adcy9 inactivation protects against atherosclerosis, but only in the absence of CETP activity. This atheroprotection may be explained by decreased macrophage accumulation and proliferation in the arterial wall, and improved endothelial function and autonomic tone.
Deletion of adenylyl cyclase type 9 results in a left ventricular diastolic dysfunction which correlates with reduced Hsp20-associated adenylyl cyclase type 9 activity and a significant 64% reduction in baseline Hsp20 phosphorylation.
miR-142-3p regulates the production of cAMP by targeting adenylyl cyclase (AC) 9 messenger RNA in CD4(+)CD25(-) T cells and CD4(+)CD25(+) T(REG) cells.
this study describes the cryo-electron microscopy structure of the bovine membrane AC9 bound to an activated G protein alphas subunit at 3.4-angstrom resolution.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.
ATP pyrophosphate-lyase 9
, adenylate cyclase type 9
, adenylate cyclase type IX
, adenylyl cyclase 9
, type IX ATP pyrophosphate-lyase
, adenylyl cyclase type 10
, adenylyl cyclase type IX
, adenylate cyclase 9
, adenylate cyclase type 9-like