Browse our ADRA2B Proteins (ADRA2B)

Human Adrenergic, alpha-2B-, Receptor (ADRA2B) interaction partners

1. Study show an associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population

2. An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with deletion in the alpha-2B adrenoreceptor gene (ADRA2B deletion).

3. Data indicate an association of arterial stiffness and platelet alpha2B-Rs gene expression.

4. full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop.

5. The ADRA2B DD genotype was associated with Hypertension and was more common in the native population of Mountain Shoria (Siberia).

6. stress administered immediately before learning selectively enhanced long-term recall in ADRA2B deletion carriers. Stress administered 30min before learning impaired recognition memory in male deletion carriers, while enhancing recognition memory in female deletion carriers.

7. This study demonstrated that a deletion variant of the ADRA2B gene encoding the alpha2b-adrenoceptor reduces the stress-induced shift from hippocampal cognitive toward dorsal striatal habit memory.

8. These results identify a beta2-adrenergic-Ca(2+)-actin axis as a new regulator of cell deformability.

9. ADRA2B SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids.

10. These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers.

11. role of GGA3 in the cell surface export of alpha2B-adrenergic receptor

12. Common polymorphisms in the ADRA2B gene are not associated with orthostatic hypotension risk in Chinese.

13. norepinephrine-related neurogenetic differences enhance the subjective vividness of perceptual experience and its emotional enhancement.

14. The results of this study suggested that ADRA2B is closely related to the individual difference in human attention orientation, but not to the individual difference in emotional processing.

15. ADRA2B deletion carriers showed decreased neural activity in the amygdala when recognizing emotional faces in control condition and increased amygdala activity under stress.

16. The ADRA2B deletion variant may selectively predict stress effects on memory in females.

17. Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.

18. Carrying the ADRA2B deletion variant enhances the relationship between arousal at encoding and subsequent memory for moderately arousing events.

19. ADRA2B mutations are associated with emotional subjectivity of viusal perception.

20. The ADRA2b deletion variant, which was previously associated with vasoconstriction, to emotional memory and visual perception.

Mouse (Murine) Adrenergic, alpha-2B-, Receptor (ADRA2B) interaction partners

1. alpha2B KO mice exhibit altered locomotor behaviors and compulsive burying behavior, are acutely sensitive to the stereotypy effects of the psychostimulant amphetamine; an identical tendency in alpha2C KO mice administered the alpha2B-receptor-selective antagonist AGN-209419 with amphetamine. Findings suggest a compulsive phenotype for alpha2B KO mice, and a broader role for the alpha2B receptor.

2. Data indicate that In arrestin 3 deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin, the hypertensive response is enhanced.

3. Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.

4. Demonstrate that both A(2A)ARs and A(2B)ARs induce coronary flow changes through K(ATP) channels.

5. alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog-mediated proliferation of mesenchymal cells and thus prevent respiratory failure

6. alpha2B adrenoceptor regulated expression is examined in mouse brain development

7. by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin reduces arrestin- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase activity after endocytosis

8. Loss of Adra2b increases magnitude of hypertension following nitric oxide synthase inhibition.

9. alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta.

10. Overexpression of the alpha(2B)-AR gene leads to increased production of alpha(2B)-AR protein in brain regions known to regulate central sympathetic outflow, thus resulting in sustained BP elevation.