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Full name:: Adrenergic, alpha-2B-, Receptor Proteins (ADRA2B)

On www.antibodies-online.com are 4 Adrenergic, alpha-2B-, Receptor (ADRA2B) Proteins from 1 different suppliers available. Additionally we are shipping ADRA2B Antibodies (40) and and many more products for this protein. A total of 46 ADRA2B products are currently listed.

Synonyms:: Adra-2b, Adra2b, ADRA2L1, ADRA2RL1, ADRARL1, alpha-2BAR, alpha2-C2, alpha2B, ALPHA2BAR, zgc:194747, [a]2B

list all proteins	Gene Name	GeneID	UniProt
	ADRA2B	151	P18089
Rat ADRA2B	ADRA2B	24174	P19328
	ADRA2B	11552
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Human Adrenergic, alpha-2B-, Receptor (ADRA2B) interaction partners

An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with deletion in the alpha-2B adrenoreceptor gene (ADRA2B deletion).
Data indicate an association of arterial stiffness and platelet alpha2B-Rs gene expression.
full length alpha2B-AR associated with GGA2 (show GGA2 Proteins) but not GGA1 (show GGA1 Proteins), its third intracellular loop was found to directly interact with both GGA1 (show GGA1 Proteins) and GGA2 (show GGA2 Proteins). More interestingly, further mapping of interaction domains showed that the GGA1 (show GGA1 Proteins) hinge region and the GGA2 (show GGA2 Proteins) GAE domain bound to multiple subdomains of the loop.
The ADRA2B DD genotype was associated with Hypertension and was more common in the native population of Mountain Shoria (Siberia).
stress administered immediately before learning selectively enhanced long-term recall in ADRA2B deletion carriers. Stress administered 30min before learning impaired recognition memory in male deletion carriers, while enhancing recognition memory in female deletion carriers.
This study demonstrated that a deletion variant of the ADRA2B gene encoding the alpha2b-adrenoceptor reduces the stress-induced shift from hippocampal cognitive toward dorsal striatal habit memory.
These results identify a beta2-adrenergic-Ca(2+)-actin axis as a new regulator of cell deformability.
ADRA2B SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids.
These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers.
role of GGA3 (show GGA3 Proteins) in the cell surface export of alpha2B-adrenergic receptor

Mouse (Murine) Adrenergic, alpha-2B-, Receptor (ADRA2B) interaction partners

alpha2B KO mice exhibit altered locomotor behaviors and compulsive burying behavior, are acutely sensitive to the stereotypy effects of the psychostimulant amphetamine; an identical tendency in alpha2C KO mice administered the alpha2B-receptor-selective antagonist AGN-209419 with amphetamine. Findings suggest a compulsive phenotype for alpha2B KO mice, and a broader role for the alpha2B receptor.
Data indicate that In arrestin 3 (show ARRB2 Proteins) deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin (show PPP1R9B Proteins), the hypertensive response is enhanced.
Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.
Demonstrate that both A(2A)ARs (show SLURP1 Proteins) and A(2B)ARs (show SLURP1 Proteins) induce coronary flow changes through K(ATP) channels.
alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog (show SHH Proteins)-mediated proliferation of mesenchymal cells and thus prevent respiratory failure
alpha2B adrenoceptor regulated expression is examined in mouse brain development
by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin (show PPP1R9B Proteins) reduces arrestin (show SAG Proteins)- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase (show MAPK1 Proteins) activity after endocytosis
Loss of Adra2b increases magnitude of hypertension following nitric oxide synthase inhibition.
alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta.
Overexpression of the alpha(2B)-AR gene leads to increased production of alpha(2B)-AR protein in brain regions known to regulate central sympathetic outflow, thus resulting in sustained BP elevation.

ADRA2B Protein Profile

Protein Summary

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine.

Alternative names and synonyms associated with ADRA2B

adrenoceptor alpha 2B (ADRA2B)
adrenoceptor alpha 2B (Adra2b)
adrenergic receptor, alpha 2b (Adra2b)
adrenergic, alpha-2B-, receptor (ADRA2B)
adrenoceptor alpha 2B (adra2b)

Adra-2b protein
Adra2b protein
ADRA2L1 protein
ADRA2RL1 protein
ADRARL1 protein
alpha-2BAR protein
alpha2-C2 protein
alpha2B protein
ALPHA2BAR protein
zgc:194747 protein
[a]2B protein

Protein level used designations for ADRA2B

, , , , , , , , , , , , , , , , , , ADRA2B adrenergic, alpha-2B-, receptor G-protein coupled receptor adrenergic receptor alpha 2B adrenergic, alpha-2B-, receptor alpha-2 adrenergic receptor subtype C2 alpha-2-adrenergic receptor-like 1 alpha-2B adrenergic receptor alpha-2B adrenoceptor alpha-2B adrenoreceptor Adrenergic alpha2B- receptor class III Adrenergic, alpha2B-, receptor class III adrenergic receptor, alpha 2b alpha-2BAR subtype alpha2-C2 alpha adrenergic receptor subtype 2B alpha 2b adrenergic receptor adrenergic receptor alpha-2B alpha-2B adrenergic receptor-like alpha(2B)AR

GENE ID	SPECIES
151	Homo sapiens
24174	Rattus norvegicus
11552	Mus musculus
459410	Pan troglodytes
516422	Bos taurus
611658	Canis lupus familiaris
641353	Sus scrofa
694825	Macaca mulatta
100051684	Equus caballus
100170318	Ovis aries
100352237	Oryctolagus cuniculus
100412057	Callithrix jacchus
100441129	Pongo abelii
266751	Danio rerio
100135476	Cavia porcellus
100478006	Ailuropoda melanoleuca

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