Browse our ADP-Ribosylation Factor 4 Proteins (ARF4)

Human ADP-Ribosylation Factor 4 (ARF4) interaction partners

1. found ADP-ribosylation factor (show ARF1 Proteins) (ARF) 4 is one of the putative target genes of Mir (show MLXIP Proteins)-221, and the direct binding relationship was further confirmed by dual-luciferase reporter assay.

2. Data suggest that, when compared to intestinal epithelial cells (IECs) from germ-free mice, IECs from mice with commensal bacteria exhibit increased expression of microRNA-21-5p; up-regulation of expression of microRNA-21-5p appears to increase IEC permeability and up-regulates ADP ribosylation factor 4 (Arf4/ARF4) in mouse and human cells.

3. ARF1 (show ARF1 Proteins)+ARF4 are required for integrity of recycling endosomes but are involved in distinct transport pathways: the pair regulates retrograde transport from endosomes to the TGN (show TG Proteins).

4. A CREB3 (show CREB3 Proteins)-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity.

5. a crucial role for class II Arf proteins (Arf4 and Arf5 (show ARF5 Proteins)) in the dengue flavivirus life cycle

6. The lipid droplets deposition and the cellular triacylglycerol content are significantly increased by siRNA-mediated depletion of Arf4.

7. sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration.

8. Arf4 regulates PLA2G6 (show PLA2G6 Proteins)-A activity together with Arf1 (show ARF1 Proteins); and gene silencing of Arf4 was shown to alter cytosolic coat protein (show GOLPH3 Proteins) I (show ANXA2 Proteins) subunit recruitment to the early secretory pathway.

9. ARF4 is a critical molecule that directly regulates cellular phospholipase D2 (show PLD2 Proteins) activity and this ARF4-mediated PLD2 (show PLD2 Proteins) activation stimulates AP-1 (show FOSB Proteins)-dependent transcription in the EGF (show EGF Proteins)-induced cellular response

10. ARF4L (show ARL4D Proteins) occurred on the plasma membrane after binding to GTP (show AK3 Proteins) and into endosomes while binding to GDP; the inactive form of ARF4L (show ARL4D Proteins) causes localization of transferrin (show Tf Proteins) receptors to the endosomes while the active form causes transport to the plasma membrane.

Mouse (Murine) ADP-Ribosylation Factor 4 (ARF4) interaction partners

1. Data suggest that, when compared to intestinal epithelial cells (IECs) from germ-free mice, IECs from mice with commensal bacteria exhibit increased expression of microRNA-21-5p; up-regulation of expression of microRNA-21-5p appears to increase IEC permeability and up-regulates ADP ribosylation factor 4 (Arf4/ARF4) in mouse and human cells.

2. ARF4 is required for Presenilin basal body localization, Notch (show NOTCH1 Proteins) signaling, and subsequent epidermal differentiation.

3. These findings are consistent with Arf4 playing a critical role in endomembrane trafficking, particularly in the pancreas, but not in ciliary function.

4. This work suggests that while Arf4 is not required for ciliary assembly, it is important for the efficient transport of fibrocystin to cilia, and also plays critical roles in non-ciliary processes

5. Findings suggest that Arf4 is a critical modulator of DG-mediated pattern separation by regulating dendritic spine development.

6. ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein Arf4 & the 2 G proteins of the Rab family--Rab11 & Rab8--linked by the Rab8 guanine nucleotide exchange factor Rabin8.

7. somal CAPS2 (show CADPS2 Proteins) is associated with the Golgi membrane, and mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (show ARF5 Proteins) to the Golgi membrane

8. a functional role for CAPS1 (show CAPS Proteins) in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 (show ARF5 Proteins) in a GDP-dependent manner.

Xenopus laevis ADP-Ribosylation Factor 4 (ARF4) interaction partners

1. The newly identified ciliary targeting VxPx motif present in rhodopsin (show RHO Proteins) binds the small GTPase (show RACGAP1 Proteins) Arf4 and regulates its association with the trans-Golgi network.

Pig (Porcine) ADP-Ribosylation Factor 4 (ARF4) interaction partners

1. swine ARF4 gene is over expressed in muscle, fat, heart, spleen, liver, and ovary and moderately expressed in lung and kidney but weakly expressed in small intestine