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Our combined data indicate that as HPMECs achieve confluence and CD31 (show HBA1 Proteins) ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 (show NEU1 Proteins) to CD31 (show HBA1 Proteins), permitting NEU1 (show NEU1 Proteins)-mediated desialylation of CD31 (show HBA1 Proteins).
Studied interactions between protein kinase C alpha (PKCalpha (show PKCa Proteins)), FOXC2 (show FOXC2 Proteins), and p120-catenin (CTNND1) in breast cancer, cell migration/ invasion; found PKCalpha (show PKCa Proteins) acts as an upstream regulator of FOXC2 (show FOXC2 Proteins), which in turn represses the expression of p120-catenin, in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Studied the association between genetic polymorphisms in the CTNND1 gene and risk of pancreatic carcinoma in Chinese population.
Results found that CTNND1 expression was significantly up-regulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)) cancer lesions compared with paired normal liver tissues and, could promote cell proliferation, migration, and invasion in vitro and in vivo. The study provides evidence that CTNND1 functions as a novel tumor oncogene (show RAB1A Proteins) in HCC (show FAM126A Proteins).
These results suggest that stabilization of delta-catenin (show CTNND2 Proteins) by Hakai (show CBLL1 Proteins) is dependent on Src (show SRC Proteins).
These results uncover a new role for p120 catenin bound to the N-cadherin (show CDH2 Proteins) precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface.
The BC cells showed the coexpression of E- and P-cadherins, as well as release of the molecules b- and p120 (show HNRNPU Proteins)-catenins into the cytoplasm of tumor cells, which leads to the activation of intracellular mechanisms for changing the structure of the cytoskeleton and the level of proliferation
recent results describing actions of p120-catenin in different phases of this pathway
The mTOR (show FRAP1 Proteins)-dependent, epithelial phenotype of TSC (show SLC12A3 Proteins) astrocytes suggests TSC1 (show TSC1 Proteins)/2 and mTOR (show FRAP1 Proteins) tune the phosphorylation level of catenin delta-1 by controlling PKCe (show PRKCE Proteins) activity, thereby regulating the mesenchymal-epithelial-transition (MET)
Src (show SRC Proteins)-dependent phosphorylation of p120(ctn) can respond rapidly to negative pressure and contribute to E-cadherin (show CDH1 Proteins) downregulation.
Stretch induced p120 degradation and the endocytosis of E-cadherin (show CDH1 Proteins), which induced beta-catenin (show CTNNB1 Proteins) translocation into the nucleus, a key event in lung injury progress and repair.
p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia.
We conclude that p120ctn is not only an adaptor and regulator of E-cadherin (show CDH1 Proteins), but is also indispensable for proper lineage commitment
p120 is required for dietary calcium suppression of oral carcinogenesis.
p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth.
a mechanistic link between E-cadherin (show CDH1 Proteins) loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso (show ZBTB33 Proteins)-dependent expression of Wnt11 (show WNT11 Proteins), is reported.
Delta-catenin (show CTNND2 Proteins) activates Rac1 and Cdc42 (show CDC42 Proteins) but inhibits RhoA (show RHOA Proteins) in lymphatic endothelial cells.
p120-catenin regulates REST and CoREST (show Rcor2 Proteins) and modulates mouse embryonic stem cell differentiation.
Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis.
p120-RhoA-GTPase-mediated signaling can differentially regulate the migratory behavior of epidermal cells, which has potential implications for chronic wound responses and cancer.
Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2.
p120ctn signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction assembly
Dyrk1A (show DYRK1A Proteins) positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (show ZBTB33 Proteins) (and canonical Wnt (show WNT2 Proteins)) gene targets such as siamois and wnt11.
The degradation machinery of the canonical Wnt (show WNT2 Proteins) pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin (show CTNNB1 Proteins).
delta-catenin (show CTNND2 Proteins) has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
cadherin-associated Src substrate
, catenin delta-1
, p120 catenin
, catenin src
, catenin (cadherin-associated protein), delta 1
, catenin delta-1 isoform 1AC
, catenin, delta 1
, catenin delta-1-like