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Membrane-proximal domains ENTH of epsin domain can form a stable hexameric core in presence of phosphatidylinositol 4,5-bisphosphate (PIP2).
Data indicate that clathrin-mediated endocytosis of proto-oncogene (show RAB1A Antibodies) protein erbB-3 (ErbB3 (show ERBB3 Antibodies)) is depending on epsin-1.
Epsins are required for Dishevelled (show DVL2 Antibodies) stability and Wnt (show WNT2 Antibodies) signalling activation in colon cancer development.
AP-2 (show GTF3A Antibodies) and epsin-1 are both required to promote efficient internalization of activated PAR1 (show MARK2 Antibodies) and recognize discrete receptor sorting signals
An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations
Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin.
epsin 1 promotes endocytosis of the ubiquitinated EGF receptor (show EGFR Antibodies)
Results show that epsin 1, an endocytic adapter protein (show TOLLIP Antibodies), regulates mitotic membrane morphology and spindle integrity in HeLa cells.
epsins 1 and 2 have a critical role in the temporal and spatial regulation of VEGFR3 (show FLT4 Antibodies) abundance and signaling in collecting lymphatic trunks during lymphatic valve formation
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
Epsins function specifically to downregulate VEGFR2 by mediating activated VEGFR2 internalization and degradation and that genetic reduction of VEGFR2 level protects against excessive angiogenesis caused by epsin loss.
Data indicate a Cbl (show CBL Antibodies)/p85 (show ECM1 Antibodies)/epsin-1 pathway in erythropoietin receptor (EpoR (show EPOR Antibodies)) endocytosis.
Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2 (show KDR Antibodies), resulting in excessive VEGF (show VEGFA Antibodies) signaling and compromised tumor vascular function.
epsin is an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface
epsin has a role as a specialized endocytic adaptor, with a critical role in the activation of Notch (show NOTCH1 Antibodies) signaling in mammals
The protein encoded by this gene binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
EH domain-binding mitotic phosphoprotein
, EPS-15-interacting protein 1
, intersectin-EH-binding protein 1
, epsin 1
, LOW QUALITY PROTEIN: epsin-1