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Transducin (show GNAT1 Proteins) activation of PDE6 appears to require interaction with both the C terminus and other regions of Pgamma to effectively relieve its inhibitory constraint.
Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D (show PDE6D Proteins) and PDE6G/H subunits in IPF lungs.
These findings demonstrate the positive role of the gamma subunit in maintaining phosphodiesterase activity and confirm the contribution of PDE6G to the etiology of retinitis pigmentosa in humans.
The C-terminus of PED gamma occludes the active site of PDE6, thereby preventing hydrolysis of cGMP.
PDEG functions to link c-Src (show SRC Proteins) and G-protein-coupled receptor kinase 2 (show ADRBK1 Proteins) in a signaling unit that regulates p42/p44 (show PSMC6 Proteins) mitogen-activated protein kinase (show MAPK1 Proteins) by epidermal growth factor (show EGF Proteins)
Crystal structures of a chimaeric PDE5 (show PDE5A Proteins)/PDE6 catalytic domain (PDE5 (show PDE5A Proteins)/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pgamma-inhibitory peptide Pgamma(70-87) have been determined at 2.9 and 3.0 A, respectively.
AIPL1-mediated production of folded PDE6C is markedly elevated in the presence of the inhibitory Pgamma-subunit of PDE6.
The presence of rod PDE6G in cones indicating functional substitution of PDE6h (show PDE6H Proteins) in mice.
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants.
phosphodiesterase 6 gamma subunit rod form
, retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
, GMP-PDE gamma
, phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide
, rod cG-PDE G
, cGMP phosphodiesterase gamma
, rod cyclic-GMP phosphodiesterase 6 gamma splice variant p3
, cyclic-GMP phosphodiesterase gamma subunit
, phosphodiesterase 6G, cGMP-specific, rod, gamma
, retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma