Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
PIK3C2A Polymorphism is associated with recurrence in non-small cell lung cancer.
Four gene signature (PTEN, PIK3C2A, ITPA (show ITPA Proteins) and BCL3 (show BCL3 Proteins)) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma (show MOK Proteins).
These results elucidated that PIK3C2A mRNA acts as a miR (show MLXIP Proteins)-124 decoy to regulate CD151 (show CD151 Proteins) and to affect hepatocellular carcinoma malignant phenotypes.
PIK3C2A was associated with bipolar disorder.
Results present evidence that PI3K-C2alpha is critical in the proper maturation of endosomes, and for coordinating the use of endosomes as an additional membrane source during autophagy.
miR-518a-5p was downregulated in imatinib-resistant gastrointestinal stromal tumors (GISTs), and the expression of miR-518a-5p was confirmed with good concordance between real-time PCR and miRNA microarray results. Luciferase reporter assays indicated that miR-518a-5p bound to the PIK3C2A 3'UTR.
Therefore, PI3K-C2A is a factor important for human cytomegalovirus replication and has a role in the production of human cytomegalovirus virions.
PI3KC2a knockdown results in rerouting of insulin (show INS Proteins) signaling and pancreatic beta cell proliferation.
MiR (show MLXIP Proteins)-206 regulates endothelial progenitor cell activities by targeting PIK3C2alpha expression.The role of PIK3C2alpha in endothelial progenitor cell function in coronary artery disease
PI3KC2alpha has a role in regulating shear-dependent platelet adhesion via regulation of membrane structure, rather than acute signalling
This is how other pik3c2a SCR map but I think more specific mapping may be appropriate (Class II Phosphatidylinositol 3-Kinases).
This study adds to this divergence by indicating a nonredundant role for PI3KC2alpha, with no role for PI3KC2beta, in regulating platelet OCS structure and overall platelet-dependent thrombus stability.
Heterozygous PI3K-C2-alpha inactivation in platelets led to reduction in phosphatidylinositol 3-monophosphate and a mislocalization of several membrane skeleton proteins known to control the interactions between the plasma membrane and cytoskeleton.
Data (including data from knockout mice) suggest that Pi3kc2a participates in tumor angiogenesis. [REVIEW]
Our studies indicate that while Vps34 (show PIK3C3 Proteins) is the main PI3P source during autophagy, class II PI3Ks also significantly contribute to PI3P generation and regulate AP biogenesis.
PI3K-C2alpha has a crucial role in vascular formation and barrier integrity
PI3KC2alpha-deficient mice developed chronic renal failure and exhibited a range of kidney lesions, including glomerular crescent (show SFRP5 Proteins) formation and renal tubule defects in early disease, which progressed to diffuse mesangial sclerosis.
phosphoinositide 3-kinase C2alpha has a role in insulin (show INS Proteins) signaling
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
C2-containing phosphatidylinositol kinase
, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
, phosphoinositide 3-kinase-C2-alpha
, phosphoinositide-3-kinase, class 2, alpha polypeptide
, ptdIns-3-kinase C2 subunit alpha
, phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
, phosphoinositide-3-kinase, class 2 alpha polypeptide
, Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
, LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha