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These results identify SNX6 as a key regulator of lamin A (show LMNA Proteins) synthesis and incorporation into the nuclear envelope.
Study observed that SNX6 increases BRMS1 (show BRMS1 Proteins)-dependent transcriptional repression. Moreover, over-expression of SNX6 was capable of diminishing trans-activation in a dose-dependent manner.
SNX6 modulates the retrograde trafficking and basal levels of BACE1 (show BACE Proteins), thereby regulating BACE1 (show BACE Proteins)-mediated APP (show APP Proteins) processing and Abeta (show APP Proteins) biogenesis
These observations indicate that in addition to SNX1 (show SNX1 Proteins)/2, SNX6 in association with the dynein/dynactin (show DCTN1 Proteins) complex drives the formation and movement of tubular retrograde intermediates.
SNX5 (show SNX5 Proteins) and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer
The authors show that SNX6 functions independently of retromer to regulate distribution of Homer1b (show HOMER1 Proteins)/c in the dendritic shaft.
These data demonstrate an endosomal, EGF (show EGF Proteins)-regulated interaction between SNX6 and GIT1 that enhances degradation of the EGFR (show EGFR Proteins), and thereby alters EGFR (show EGFR Proteins) signaling.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.
sorting nexin 6
, sorting nexin-6
, TRAF4-associated factor 2
, tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2