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anti-Human SOX9 Antibodies:
anti-Rat (Rattus) SOX9 Antibodies:
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Human Polyclonal SOX9 Primary Antibody for ICC, IF - ABIN4355424
Vestentoft, Jelnes, Hopkinson, Vainer, Møllgård, Quistorff, Bisgaard: Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver. in BMC developmental biology 2011
Show all 10 Pubmed References
Human Polyclonal SOX9 Primary Antibody for IF (p), IHC (p) - ABIN754963
Papaioannou, Mirzamohammadi, Lisse, Nishimori, Wein, Kobayashi: MicroRNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014
Show all 6 Pubmed References
Human Monoclonal SOX9 Primary Antibody for IF, IHC (p) - ABIN520382
Hodgin, Borczuk, Nasr, Markowitz, Nair, Martini, Eichinger, Vining, Berthier, Kretzler, DAgati: A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue. in The American journal of pathology 2010
Show all 4 Pubmed References
Human Monoclonal SOX9 Primary Antibody for ICC, ELISA - ABIN969568
Dupasquier, Abdel-Samad, Glazer, Bastide, Jay, Joubert, Cavaillès, Blache, Quittau-Prévostel: A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium. in Journal of cell science 2009
Show all 2 Pubmed References
Cat (Feline) Polyclonal SOX9 Primary Antibody for IHC (p), SimWes - ABIN4355427
Antunes, Tsaryk, Gonçalves, Pereira, Landes, Brochhausen, Ghanaati, Barbosa, Kirkpatrick: Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells. in Tissue engineering. Part A 2015
Show all 2 Pubmed References
Amphibian Polyclonal SOX9 Primary Antibody for DB, IHC - ABIN4355422
Sharma, Knowell, Chinaranagari, Komaragiri, Nagappan, Patel, Havrda, Chaudhary: Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. in Molecular cancer 2014
Human Polyclonal SOX9 Primary Antibody for IF, IHC (p) - ABIN272082
Zhang, Ding, Nie, Li-Ling, Zhang, Zhang, Chen, Li, Ding: Association of hsa-miR‑145 overexpression in human testicular cells with male infertility. in Molecular medicine reports 2015
Zebrafish (Danio rerio) Polyclonal SOX9 Primary Antibody for ELISA - ABIN408740
Yan, Willoughby, Liu, Crump, Wilson, Miller, Singer, Kimmel, Westerfield, Postlethwait: A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. in Development (Cambridge, England) 2005
Human Monoclonal SOX9 Primary Antibody for ELISA, WB - ABIN562960
Wainwright, Svingen, Ng, Wicking, Koopman: Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice. in Developmental biology 2014
Cow (Bovine) Polyclonal SOX9 Primary Antibody for FACS, WB - ABIN2780338
Vidal, Ortonne, Schedl: SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. in Journal of cutaneous pathology 2008
Show all 2 Pubmed References
miR (show MLXIP Antibodies)-185 inversely regulates SOX9 expression in non-small cell lung cancer.
Data suggest that the SOX9 transcription factor (SOX9)-fibroblast growth factor receptor 2 (show FGFR2 Antibodies) (FGFR2b) feed-forward loop has a lineage dependency role in pancreatic ductal adenocarcinoma (PDAC).
Depletion of KDM6A (show KDM6A Antibodies) inhibits the expression of SOX9, Col2a1 (show COL2A1 Antibodies), ACAN (show ACAN Antibodies) and results in increased H3K27me3 and decreased H3K4me3 levels.
Our results demonstrate that SOX9 plays a crucial role in chordoma. Targeting SOX9 provides a new rationale for treatment of chordoma
Odd-skipped related 1 (OSR1 (show OSR1 Antibodies)) downregulated the activity of the Wnt (show WNT2 Antibodies) signaling pathway by suppressing the expression of sex-determining region Y (show SRY Antibodies)-box 9 (SOX9) and beta-catenin (show CTNNB1 Antibodies).
Sex determining region Y (show SRY Antibodies) box 9 (Sox9) plays an important role in chemoresistance by the induction of stemness in pancreatic cancer cells.
Knockdown of SOX9 expression by RNA interference reduces cell proliferation and induces apoptosis of lung cancer cells, which was consistent with the results obtained from silencing the expression of LASP-1 (show LASP1 Antibodies) in NCIH1650 cells.
This study provides evidence of a novel signaling pathway for TGF-beta (show TGFB1 Antibodies) in cartilage that involves post-translational stabilization of Sox9 protein through Smad2 (show SMAD2 Antibodies)/3 and p38 (show CRK Antibodies) signaling pathways.
In conclusion, these results highlight the potential therapeutic effects of Andro in treatment of chondrosarcoma via targeting the TCF-1 (show HNF1A Antibodies)/SOX9 axis.
These results identify a functional role for SOX9 in regulating colorectal cancer cell plasticity and metastasis, and provide a strong rationale for a rapamycin-based therapeutic strategy.
Analysis of tissue maturation markers showed an increase in COLL II and a decrease in SOX9 expression in the swine tibial menisci with age.
The expression of the differentiation and stemness genes, FN1 (show FN1 Antibodies) and SOX9, is accompanied by cell proliferation.
data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR (show UTS2R Antibodies) is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits
HIF-1alpha (show HIF1A Antibodies) activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
these findings widen our current knowledge of SOX9 targets in early chondrogenesis and call for new studies to identify the pioneer and transactivating factors that act upstream of or along with SOX9 to prompt chromatin remodeling and specific gene activation at the onset of chondrogenesis and other processes.
The data support a model of SOX9-GLI (show GLI1 Antibodies)-FOXA phasic gene regulatory network in chondrocyte development. Together, SOX9-GLI (show GLI1 Antibodies) auto-regulate and cooperate to activate and repress genes in proliferating chondrocytes. Upon hypertrophy, FOXA competes with SOX9, and control toward terminal differentiation passes to FOXA, RUNX, AP1 (show JUN Antibodies) and MEF2 (show MEF2C Antibodies) factors.
Ctgf (show CTGF Antibodies) is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells.
MOB1 (show HOPX Antibodies)-dependent YAP1 (show YAP1 Antibodies)/TAZ (show TAZ Antibodies)-TEAD complex functions as a transcriptional repressor of SOX9 and thereby negatively regulates chondrogenesis.
the novel role of Tgfb2 (show TGFB2 Antibodies), Fbxl18 (show FBXL18 Antibodies), and Tle3 (show TLE3 Antibodies) in formation of Sox5 (show SOX5 Antibodies), Sox6, and Sox9 dependent tissues.
A critical level of endogenous active SOX9 needed to maintain colorectal tumor cell growth.
The spatiotemporal expression of Sox9 suggested its possible involvement during mouse incisor development.
HSP60 (show HSPD1 Antibodies) regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
both the local oxygen environment and WT1 (show WT1 Antibodies), which enhances KDR (show KDR Antibodies) expression, contribute to sex-specific Sox9 expression in developing murine gonads
This resulted in a delay in the birth of OPCs and subsequent developmental aberrations in these cells in the Sox9-deficient mice.
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
SRY (sex determining region Y)-box 9
, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
, transcription factor SOX-10
, SRY (sex-determining region Y)-box 9 protein
, SRY-related HMG-box, gene 9
, transcription factor SOX-9
, SRY-box containing protein 9
, SRY-box containing gene 9
, transcription factor SOX9