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anti-Mouse (Murine) WNT5B Antibodies:
anti-Human WNT5B Antibodies:
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opposing gradients of Wnt5a (show WNT5A Antibodies) and Wnt5b and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5b activated known calcium-dependent signaling pathways and JNK (show MAPK8 Antibodies), a component of the planar cell polarity pathway.
Secreted Wnt (show WNT2 Antibodies) glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 (show FOXN2 Antibodies) expression in both autocrine and paracrine fashions. Wnt (show WNT2 Antibodies) molecules therefore provide regulatory signals critical for thymic function.
Data indicate that Wnt5a (show WNT5A Antibodies) and Wnt5b control the pace of transitions between different chondrocyte zones.
Wnt5b may promote adipogenesis in 3T3-L1 cells, at least in part, by antagonizing the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway
hCG (show CGA Antibodies) was found to up-regulate these wnt (show WNT2 Antibodies) ligands in mouse mammary gland, independent of the changes in ovarian steroidogenesis
this study aimed at defining the expression profile and function of Wnt5a (show WNT5A Antibodies) and Wnt5b during adipogenesis by determining their effect on aP2 (show TFAP2A Antibodies) and PPARgamma (show PPARG Antibodies) expression and assessing the level of beta-catenin (show CTNNB1 Antibodies) translocation in mouse 3T3-L1 preadipocytes.
Together these findings provide important and novel insights into the role of canonical Wnt (show WNT2 Antibodies) signals during the patterning of vertebrate ectoderm and indicate that Wnt (show WNT2 Antibodies) inhibition plays a central role in the process of neural induction.
exaggerated WNT-5B expression upon cigarette smoke exposure in the bronchial epithelium of COPD (show ARCN1 Antibodies) patients leads to TGF-beta (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies)-dependent expression of genes related to airway remodelling
were not able to replicate or further verify the genetic association of polymorphisms in WNT4 (show WNT4 Antibodies) and WNT5B with bone mineral density
the data suggest that WNT5B induces tube formation by regulating the expression of Snail (show SNAI1 Antibodies) and Slug proteins through activation of canonical and non-canonical WNT (show WNT2 Antibodies) signalling pathways.
Noncanonical Wnt (show WNT2 Antibodies) signaling via Wnt5a (show WNT5A Antibodies)/5b/11 may have role in the pathogenesis of aortic valve calcification.
WNT-5B induces IL-6 (show IL6 Antibodies) and CXCL8 (show IL8 Antibodies) secretion in pulmonary fibroblasts.
overexpression of WNT5B significantly increased cell proliferation, migration and invasion capacities of the COLO 205 cells in vitro. WNT5B may play an important role in the tumorigenesis of colorectal cancer.
results suggest that Wnt5b-associated exosomes promote cancer cell migration and proliferation in a paracrine manner
these results suggest that TGF-beta1 (show TGFB1 Antibodies) stimulates HSC-4 cell invasion through the Slug/Wnt-5b/MMP-10 (show MMP10 Antibodies) signalling axis.
This study identified WNT5B and CTNNBL1 for peak bone mineral density and body composition in males from the Han Chinese ethnic group.
The interaction between Wnt (show WNT2 Antibodies) isoforms and their LRP6 (show LRP6 Antibodies) cognate receptor depends on the jutting loop present in Wnt3a (show WNT3A Antibodies) but absent in Wnt5b.
the chaperon Wls (show WLS Antibodies) and its ligands Wnt9a (show WNT9A Antibodies) and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (show FRZB Antibodies) and Gpc4 (show GPC4 Antibodies).
disruption of wls (show WLS Antibodies) resulted in a significant loss of craniofacial bone, whereas lack of gpc4 (show GPC4 Antibodies), wnt5b and wnt9a (show WNT9A Antibodies) resulted in severely delayed endochondral ossification.
novel mechanism for Wnt5b and Gpc4 (show GPC4 Antibodies) regulation of chondrocyte behavior that is independent of the core Wnt (show WNT2 Antibodies)/PCP (show PRCP Antibodies) molecules and differs from their collaborative action of controlling cell movements during gastrulation
In embryos overexpressing lbx1b (show Lbx1 Antibodies), wnt5b, a ligand of the non-canonical Wnt (show WNT2 Antibodies)/planar cell polarity (PCP (show PRCP Antibodies)) pathway, was significantly downregulated.
Swap70b and Def6a (show DEF6 Antibodies) delineate Wnt11 (show WNT11 Antibodies) and Wnt5b signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
CNBP (show CNBP Antibodies) up-regulates tbx2b and smarca5 (show SMARCA5 Antibodies), and down-regulates wnt5b gene expression.
def6 (show DEF6 Antibodies) morphants phenocopy Wnt5b mutants and ectopic overexpression of def6 (show DEF6 Antibodies) essentially rescues Wnt5b morphants, indicating a novel role for def6 (show DEF6 Antibodies) as a central GEF (show SLC2A4RG Antibodies) downstream of Wnt5b signaling
identify rgs3 (show RGS3 Antibodies) as having an overlapping expression pattern with wnt5b in zebrafish and reveal that individual knockdown of either rgs3 (show RGS3 Antibodies) or wnt5b gene function produces similar somite patterning defects.
Data suggest that full-length Ryk (show RYK Antibodies) conveys Wnt5b signals in a directional manner during gastrulation.
Data suggest that the Wnt-5 loss-of-function defect is consistent with calcium modulation having an antagonistic interaction with Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants.
wingless-type MMTV integration site family, member 5B
, protein Wnt-5b
, protein Wnt-5c
, wingless-type MMTV integration site family, member 5
, WNT-5B protein
, wingless-related MMTV integration site 5B
, pipe tail