Protein Summary

Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Alternative names and synonyms associated with CTDSP2

• CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (ctdsp2) antibody
• CTD small phosphatase 2 L homeolog (ctdsp2.L) antibody
• CTD small phosphatase 2 (CTDSP2) antibody
• CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (Ctdsp2) antibody
• CTD small phosphatase 2 (Ctdsp2) antibody

• AI586070 antibody
• CTDSP2 antibody
• D10Ertd73e antibody
• fb16c04 antibody
• MGC68415 antibody
• Show all synonym aliases
• OS-4 antibody
• OS4 antibody
• PSR2 antibody
• SCP2 antibody
• wu:fb16c04 antibody
• zgc:77714 antibody

Protein level used designations for CTDSP2

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 , CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 , Os4 , nuclear LIM interactor-interacting factor 2 , NLI-interacting factor 2 , conserved gene amplified in osteosarcoma , protein OS-4 , small C-terminal domain phosphatase 2 , small CTD phosphatase 2 , nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4) , nuclear LIM interactor-interacting factor 2-like