Browse our SEC63 Proteins (SEC63)

Full name:: SEC63 Homolog (S. Cerevisiae) Proteins (SEC63)

On www.antibodies-online.com are 7 SEC63 Homolog (S. Cerevisiae) (SEC63) Proteins from 3 different suppliers available. Additionally we are shipping SEC63 Antibodies (38) and and many more products for this protein. A total of 50 SEC63 products are currently listed.

Synonyms:: 5730478J10Rik, AI649014, AW319215, DNAJC23, ERdj2, PRO2507, SEC63-like, SEC63L, zgc:92718

list all proteins	Gene Name	GeneID	UniProt
	SEC63	11231	Q9UGP8
	SEC63	140740	Q8VHE0
Rat SEC63	SEC63	309858
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SEC63 Proteins (SEC63) by Origin

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Relevant Pathways for SEC63 Proteins

ER-Nucleus Signaling

More product categories related to SEC63 Protein

More Proteins for SEC63 Interaction Partners

Human SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

Results suggest that loss of PRKCSH (show PRKCSH Proteins) and SEC63 leads to general defects in ciliogenesis, while quenching of the Wnt (show WNT2 Proteins) signaling cascade is cholangiocyte-restricted.
a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease
Phosphorylation of Sec63 by CK2 (show CSNK2A1 Proteins) enhanced its binding to Sec62 (show TLOC1 Proteins)
Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.
Silencing the human SEC63 genes inhibits transport of only a subset of signal-peptide-containing precursor proteins to endoplasmic reticulum.
identified nucleoredoxin (show NXN Proteins) as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt (show WNT2 Proteins) signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease
identified a total of 26 novel mutations in PRKCSH (show PRKCSH Proteins) (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations
Mutations in SEC63 cause autosomal dominant polycystic liver disease, suggesting a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicating noncilial ER proteins in human polycystic disease.
Sec63p expression was observed in all cyst epithelia regardless of mutational state. And, Cystogenesis in SEC63-associated PCLD (show PRKCSH Proteins) occurs via a different mechanism.

Mouse (Murine) SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

SEC63 function regulates IRE1alpha (show ERN1 Proteins)/XBP1 (show XBP1 Proteins) activation. SEC63 and XBP1 (show XBP1 Proteins) are required for GPS cleavage and maturation of PC1 (show PCSK1 Proteins), protecting against polycystic disease.
The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.
Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.
SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.

Zebrafish SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

disruption of sec63 leads to abnormalities in myelinating glia in both the central and peripheral nervous systems

SEC63 Protein Profile

Protein Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Alternative names and synonyms associated with SEC63

SEC63 homolog, protein translocation regulator (SEC63)
SEC63-like (S. cerevisiae) (Sec63)
SEC63 homolog, protein translocation regulator (Sec63)
SEC63 homolog, protein translocation regulator (sec63)
SEC63 homolog, protein translocation regulator L homeolog (sec63.L)

5730478J10Rik protein
AI649014 protein
AW319215 protein
DNAJC23 protein
ERdj2 protein
PRO2507 protein
SEC63-like protein
SEC63L protein
zgc:92718 protein

Protein level used designations for SEC63

translocation protein SEC63 homolog , SEC63-like protein , SEC63-like

GENE ID	SPECIES
11231	Homo sapiens
140740	Mus musculus
309858	Rattus norvegicus
436861	Danio rerio
495416	Xenopus laevis
421774	Gallus gallus
475016	Canis lupus familiaris
541040	Bos taurus
100328696	Oryctolagus cuniculus
100728680	Cavia porcellus
100152304	Sus scrofa
100072096	Equus caballus

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