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we report for the first time that PKD1 (show PKD1 ELISA Kits) was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 (show PKD1 ELISA Kits) repression.
They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.
Results identify FRS2 as an oncogene (show RAB1A ELISA Kits) in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications.
Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib.
The signaling complex appears to integrate the input from FGFR (show FGFR2 ELISA Kits) and EphA4 (show EPHA4 ELISA Kits), and release the output signal through FRS2alpha.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.
The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.
Patient with pigmentation disorders and vitiligo (show MITF ELISA Kits) show decreased expression of mRNA.
Data indicate that the FGFR (show FGFR2 ELISA Kits)/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas.
a novel signaling network containing FRS2, CAP and flotillin-1 (show FLOT1 ELISA Kits)
Fgfr (show FGFR2 ELISA Kits) signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
Analysis of a mutant Fgfr1 (show FGFR1 ELISA Kits) allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 (show SOX2 ELISA Kits) maintenance can be regulated by MAP kinase (show MAPK1 ELISA Kits).
data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK (show EPHB2 ELISA Kits) pathway components in the epididymis.
Genetic evidence further supports that the formation of an Frs2alpha-Shp2 (show PTPN11 ELISA Kits) complex and its recruitment to FGF receptors are crucial for downstream ERK (show EPHB2 ELISA Kits) signaling in this process.
Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
The FGF signaling axis activates mTOR (show FRAP1 ELISA Kits) via the FGF receptor (show FGFR2 ELISA Kits) substrate 2alpha (FRS2alpha)-mediated PI3K/Akt (show AKT1 ELISA Kits) pathway, and suppresses autophagy activity in MEFs.
although Fgfr2 (show FGFR2 ELISA Kits) and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.
Msx2 and Runx2 (show RUNX2 ELISA Kits) likely function together to induce PC-1 (show PCSK1 ELISA Kits) gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK (show MAPK1 ELISA Kits) signaling pathway
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
fibroblast growth factor receptor substrate 2
, FGFR signalling adaptor
, FGFR substrate 2
, FGFR-signaling adaptor SNT
, suc1-associated neurotrophic factor target 1