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Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (show CD4 Proteins)(+) T cell proliferation and uncover a suppressive role for Irf4 (show IRF4 Proteins) in TH2 polarization; halving Irf4 (show IRF4 Proteins) gene-dosage leads to increases in GATA3 (show GATA3 Proteins)(+) and IL-4 (show IL4 Proteins)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (show WT1 Proteins) promoter, and enhanced WT1 (show WT1 Proteins) promoter transactivation and knockdown of WT1 (show WT1 Proteins) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (show WT1 Proteins) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (show PRL Proteins)) and insulin-like growth factor binding protein-1 (IGFBP-1 (show IGFBPI Proteins)) expression and transformation in vitro.
DNMT1 (show DNMT1 Proteins) causes NR4A1 DNA hypermethylation and blocks insulin (show INS Proteins) signaling in an Chinese patients with type 2 diabetes
Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways.
mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
NR4A sub-family of nuclear orphan receptors (Nor-1 (show NR4A3 Proteins), Nurr-1 (show NR4A2 Proteins) and Nur-77) may have a role in trophoblastic cell differentiation.
beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
These results suggest that berberine-induced activation of AMPK (show PRKAA1 Proteins) may contribute to hepatic FGF21 (show FGF21 Proteins) expression via NUR77.
we found that KLF6 (show KLF6 Proteins) transcriptionally cooperates with NUR77 and SF1 (show SF1 Proteins)
Ca(2 (show CA2 Proteins)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (show MEF2C Proteins), AP1 (show JUN Proteins), and CREB (show CREB1 Proteins) transcription factors thus demonstrating an important interplay between the Ca(2 (show CA2 Proteins)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (show BCL2L11 Proteins) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (show TRAF2 Proteins). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (show SQSTM1 Proteins), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.
Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B