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Results identified the diffuse B-cell lymphoma homology (DH) domain of Vav3 that interacts with the N-terminal region of AR-V7 (splice variants) and increases its expression in castration-resistant prostate cancer (CRPC). This interaction disrupted AR-V7 interaction with other AR coactivators like Src1 and Vav2.
We then explore the consequences of phorbol ester binding to a modified Vav3 in which the C1 domain has been altered to allow phorbol ester binding. We find both disruption of the guanyl (show GUCA2A Proteins) nucleotide exchange activity of the modified Vav 3 as well as a shift in localization to the membrane upon phorbol ester treatment.
Overexpression of Vav3 is an independent risk factor for prognosis of gastric cancer, and can be used as a prognostic indicator.
Vav3 is a novel TRAF6 (show TRAF6 Proteins) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.
this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK (show MAPK1 Proteins) activation
Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone
Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells
Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK (show EPHB2 Proteins) pathway
Data show that microRNA miR (show MLXIP Proteins)-499-5p targeted 3' untranslated regions (3'-UTR) of vav 3 oncogene protein (VAV3).
Results found that OSR2, VAV3, and PPFIA3 (show PPFIA3 Proteins) were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC.
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Platelet P-Rex and Vav (show VAV1 Proteins) family Rac (show AKT1 Proteins)-GEFs play important proinflammatory roles in leukocyte recruitment.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin (show INS Proteins) state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type.
Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Vav3 collaborates with p190 (show CNTNAP1 Proteins)-BCR-ABL (show ABL1 Proteins) in lymphoid progenitor leukemogenesis, proliferation, and survival.
Dectin-1 (show CLEC7A Proteins) activates the integrin Mac-1 (show ITGAM Proteins) in neutrophils via Vav1 (show VAV1 Proteins) and Vav3 signaling to promote Candida albicans clearance.
study discloses an essential and nonredundant role for this Vav (show VAV1 Proteins) family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates
CD36 (show CD36 Proteins) contributes to activation of Vav-1 (show VAV1 Proteins), -2, and -3 in aortae from hyperlipidemic mice
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
vav 3 oncogene
, guanine nucleotide exchange factor VAV3
, vav 3 protein