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Genetic variation in MEOX2 (show MEOX2 Proteins), but not TCF15, is a strong predictor of CHD (show CHDH Proteins). Further experimental studies should elucidate the underlying molecular mechanisms.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox (show MEOX2 Proteins)2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
Activation of TGFbeta (show TGFB1 Proteins) recruits p300 (show EP300 Proteins) to the KLF5 (show KLF5 Proteins)-Smad (show SMAD1 Proteins) complex to acetylate KLF5 (show KLF5 Proteins), and the complex with acetylated KLF5 (show KLF5 Proteins) binds to the Smad (show SMAD1 Proteins) binding element and alters the binding of other factors to p15 (show CDKN2B Proteins) promoter to induce its transcription
Micrarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2 (show MEOX2 Proteins)/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
The data demonstrate that PARAXIS initiates and stabilizes somite epithelialization by integrating signals from multiple pathways to control the reorganization of the ECM (show MMRN1 Proteins), cytoskeleton, and adhesion junctions during MET.
Tcf15 contributes toward steering pluripotent cells in the direction of somatic lineages and that it will serve as a valuable tool for monitoring and interrogating early developmental transitions.
The molecular characterization of paraxis is reported inh the paraxialmesoderm and somites.
analysis of developmental expression of Xenopus paraxis
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding.
, basic helix-loop-helix transcription factor 15
, class A basic helix-loop-helix protein 40
, protein bHLH-EC2
, transcription factor 15
, paraxis-like protein
, bHLH-EC2 protein
, Protein bHLH-EC2
, basic helix-loop-helix transcription factor
, LOW QUALITY PROTEIN: transcription factor 15
, transcription factor 15 (basic helix-loop-helix)