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Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription
The molecular characterization of paraxis is reported inh the paraxialmesoderm and somites.
analysis of developmental expression of Xenopus paraxis
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding.
, basic helix-loop-helix transcription factor 15
, class A basic helix-loop-helix protein 40
, protein bHLH-EC2
, transcription factor 15
, paraxis-like protein
, bHLH-EC2 protein
, Protein bHLH-EC2
, basic helix-loop-helix transcription factor
, LOW QUALITY PROTEIN: transcription factor 15
, transcription factor 15 (basic helix-loop-helix)