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anti-Mouse (Murine) Antibodies:
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Bat Polyclonal B4GALT5 Primary Antibody for WB - ABIN6746272
Dzwonek, Preobrazhenska, Cazzola, Conidi, Schellens, van Dinther, Stubbs, Klippel, Huylebroeck, ten Dijke, Verschueren: Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells. in Molecular cancer research : MCR 2009
Show all 3 Pubmed References
Results demonstrated B4GalT5 downregulation improved insulin resistance by promoting adipogenic commitment and decreasing M1 macrophage infiltration.
beta-1,4-GalT-V gene/protein expression is specifically increased in colorectal cancer, compared to visibly normal tissue. Furthermore, we observed a marked increase in its enzymatic activity, and its product lactosylceramide. beta-1,4-GalT-V may serve as a diagnostic and therapeutic biomarker for the progression of colorectal cancer.
2.3-kb 5'-flanking region of the human beta-1,4-GalT V gene was cloned and the region -116/-18 relative to the transcription start site as that having promoter activity.
B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of multidrug resistance of human leukemia cells.
The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 and Ets-1 in cancer cells.(review)
These data reveal a critical role of beta1,4GalT V in the self-renewal and tumorigenicity of glioma-initiating cells.
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line
results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy
Ets-1 enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 gene in cancer cells
sulfated keratan sulfate is produced by beta3GNT7, beta4GalT4, CGn6ST, and KSG6ST
The expression of Beta4GalT5 gene decreases through reduced expression of the Sp1 gene and protein upon differentiation of pre-adipocytes to adipocytes.
Lactosylceramide synthase is encoded by B4galt5 and 6 genes in the central nervous system, and these genes are indispensable for neuronal maturation, perineuronal nets formation, and axonal and myelin formation.
These results strongly indicate that the amounts of Lac-Cer synthesized by beta4GalT5 correlate with the tumorigenic potentials of malignantly transformed cells.
Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
beta-1,4-galactosyltransferase V is involved in lactosylceramide biosynthesis
Loss of beta4Gal-T5 is associated with hematoma and defect in extra-embryonic development.
The results indicate that the growth is delayed by one to one and half day in B4galt5-/- embryos when compared to B4galt5+/- embryos, which results in early death of the embryos by E10.5, probably due to hematopoietic and/or placental defects.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
, beta-1,4-GalT II
, beta-1,4-GalT IV
, beta-1,4-GalTase 5
, beta-1,4-galactosyltransferase 5
, beta-1.4-galactosyltransferase V
, beta4-GalT IV
, beta-1,4-galactosyltransferase V