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anti-Mouse (Murine) Antibodies:
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Bat Polyclonal B4GALT5 Primary Antibody for WB - ABIN610843
Dzwonek, Preobrazhenska, Cazzola, Conidi, Schellens, van Dinther, Stubbs, Klippel, Huylebroeck, ten Dijke, Verschueren: Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells. in Molecular cancer research : MCR 2009
Show all 3 Pubmed References
B4GALT1 (show B4GALT1 Antibodies) and B4GALT5, two members of B4GALT (show B4GALNT2 Antibodies) gene family, are involved in the development of multidrug resistance of human leukemia cells.
The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 (show PSG1 Antibodies) and Ets-1 (show ETS1 Antibodies) in cancer cells.(review)
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line
results suggest that GalT (show GALT Antibodies) V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy
Ets-1 (show ETS1 Antibodies) enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 (show PSG1 Antibodies) gene in cancer cells
sulfated (show SULF1 Antibodies) keratan sulfate is produced by beta3GNT7 (show B3GNT7 Antibodies), beta4GalT4, CGn6ST, and KSG6ST
These results strongly indicate that the amounts of Lac (show LCT Antibodies)-Cer (show CBLN1 Antibodies) synthesized by beta4GalT5 correlate with the tumorigenic potentials of malignantly transformed cells.
Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase (show UGCG Antibodies) and lactosylceramide synthase showed marked reduction in tumor volume.
The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 (show SP1 Antibodies) and Ets-1 (show ETS1 Antibodies) in cancer cells.(review)
beta-1,4-galactosyltransferase V is involved in lactosylceramide biosynthesis
Loss of beta4Gal-T5 is associated with hematoma and defect in extra-embryonic development.
The results indicate that the growth is delayed by one to one and half day in B4galt5-/- embryos when compared to B4galt5+/- embryos, which results in early death of the embryos by E10.5, probably due to hematopoietic and/or placental defects.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
, beta-1,4-GalT II
, beta-1,4-GalT IV
, beta-1,4-GalTase 5
, beta-1,4-galactosyltransferase 5
, beta-1.4-galactosyltransferase V
, beta4-GalT IV
, beta-1,4-galactosyltransferase V