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anti-Human Biglycan Antibodies:
anti-Mouse (Murine) Biglycan Antibodies:
anti-Rat (Rattus) Biglycan Antibodies:
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Human Polyclonal Biglycan Primary Antibody for IHC, ELISA - ABIN188683
Antipova, Orgel: Non-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritis. in PLoS ONE 2012
Show all 4 Pubmed References
Human Polyclonal Biglycan Primary Antibody for IHC, IHC (p) - ABIN4284625
Van Bockstal, Lambein, Van Gele, De Vlieghere, Limame, Braems, Van den Broecke, Cocquyt, Denys, Bracke, Libbrecht, De Wever: Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion. in Oncoscience 2015
Show all 2 Pubmed References
Human Polyclonal Biglycan Primary Antibody for IF (p), IHC (p) - ABIN872817
Huang, Zou, Shi, Zhang, Pen, Zhang, Gao, Wang: The effect of electroacupuncture on the extracellular matrix synthesis and degradation in a rabbit model of disc degeneration. in Evidence-based complementary and alternative medicine : eCAM 2014
Show all 2 Pubmed References
Human Monoclonal Biglycan Primary Antibody for IHC (p), IP - ABIN560056
Zhang, Lee, Young, Wang: The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3. in Translational stroke research 2015
Human Polyclonal Biglycan Primary Antibody for WB - ABIN513714
Gasimli, Stansfield, Nairn, Liu, Paluh, Yang, Dordick, Moremen, Linhardt: Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. in Glycoconjugate journal 2013
Human Polyclonal Biglycan Primary Antibody for IHC, ELISA - ABIN334359
Chen, Lenschow, Tiede, Fischer, Kalthoff, Ungefroren: Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Results identified loss-of-function mutation in BGN gene in patients with an X-linked syndromic form of severe thoracic aortic aneurysms and dissections (TAAD) confirming BGN as causative gene in severe form of TAAD.
After the first year of smoking abstinence the levels of BGN expression and carotid-femoral pulse wave velocity are significantly improved as compared to baseline.
study reports a temporal relationship between altered placental biglycan expression and subsequent development of fetal growth restriction/small for gestational age.
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (p = 0.0008) and Lumican (show LUM Antibodies) (p = 0.01) and lower expression of Decorin (show DCN Antibodies) (p < 0.0001) in urothelial carcinoma of bladder
Mutation in BGN gene is associated with X-Linked Spondyloepimetaphyseal Dysplasia.
biglycan exerts an important role in cell proliferation, migration, invasion and apoptosis in colon cancer.
BGN might play an important role on metastasis in human endometrial cancer and it might be a target marker for the molecular therapy of advanced and recurrence endometrial cancer.
This study demonstrated that the small leucine-rich proteoglycan (show Vcan Antibodies) BGN accumulates in CADASIL (show NOTCH3 Antibodies) and binds to NOTCH3 (show NOTCH3 Antibodies).
Biglycan may have a role in development of vascular damage in smokers
BGN is a factor secreted by peritubular cells to modulate FGFR3c signaling and thus contributes to the regulation of spermatogonial maintenance
Results show that Bgn plays a role in the process of angiogenesis during fracture healing, and that effect appears to be partially mediated through endostatin (show COL18A1 Antibodies) suppression.
Asporin (show ASPN Antibodies) deficiency changes skin glycosaminoglycan composition, and decorin (show DCN Antibodies) and biglycan content, which may explain the changes in skin mechanical properties.
Biglycan plays a protective role during the progression of atherosclerosis in ApoE (show APOE Antibodies)-deficient mice by inhibiting thrombin (show F2 Antibodies) generation.
These genes were concordantly induced by TAC (show IL2RA Antibodies) in WT but not in biglycan KO mice. CONCLUSIONS: Left ventricular pressure overload induces biglycan expression in cardiac fibroblasts. Ablation of biglycan improves cardiac function and attenuates left ventricular hypertrophy and fibrosis after long-term pressure overload.
Importance of biglycan and decorin (show DCN Antibodies) as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.
Biglycan deficiency leads to loosely packed aortic collagen fibers, increased susceptibility of aortic elastin (show ELN Antibodies) fibers to angII-induced stress, and up-regulation of vascular perlecan (show HSPG2 Antibodies) content.
Biglycan signaling supported fetal membrane remodeling during early gestation in the absence of concomitant changes in TGFbeta (show TGFB1 Antibodies) levels.
Lumican (show LUM Antibodies) and biglycan influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Biglycan-triggered TLR-2 (show TLR2 Antibodies)- and TLR-4 (show TLR4 Antibodies)-signaling exacerbates the pathophysiology of ischemic acute kidney injury.
De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88 (show MYD88 Antibodies)/TRIF (show RNF138 Antibodies) pathways.
Data show that biglycan, collagen type I, collagen type II, decorin (show DCN Antibodies), and versican (show Vcan Antibodies) were significantly affected by vibration duration, frequency, and amplitude.
biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
The results indicate that CTGF (show CTGF Antibodies) suppresses the synthesis of biglycan but newly induced that of decorin (show DCN Antibodies) in the cells when the cell density is low.
LDL electrostatic interactions with decorin (show DCN Antibodies) and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
Bgn regulates BMP4 (show BMP4 Antibodies) signaling through modulation of Chordin (show CHRD Antibodies) anti-BMP4 (show BMP4 Antibodies) activity.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.
, bone/cartilage proteoglycan I
, bone/cartilage proteoglycan-I
, dermatan sulphate proteoglycan I
, small leucine-rich protein 1A
, Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)
, bone/cartilage proteclycan 1
, leucine-rich PG I