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sex-specific allele combinations of BGN, COL5A1, and DCN (show DCN Proteins), as well as eight miRNA recognition sequences, were associated with altered susceptibility to anterior cruciate ligament ruptures
high Bgn expression levels promote a more dense collagen architecture, leading to increased tissue stiffness. This increased tissue stiffness leads to higher integrin-beta1 expression on melanoma cells, which promotes their invasiveness.
The expression of hBGN in the skeletal muscle of the treated mice was 1.34-fold higher than that of the native mouse Bgn (mBgn). The low transduction efficiency and improved motor functions suggest that biglycan expressed in a small number of muscle fibers was likely to have been secreted and anchored to the cell surface throughout the whole muscular fibers
Results identified loss-of-function mutation in BGN gene in patients with an X-linked syndromic form of severe thoracic aortic aneurysms and dissections (TAAD) confirming BGN as causative gene in severe form of TAAD.
After the first year of smoking abstinence the levels of BGN expression and carotid-femoral pulse wave velocity are significantly improved as compared to baseline.
study reports a temporal relationship between altered placental biglycan expression and subsequent development of fetal growth restriction/small for gestational age.
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (p = 0.0008) and Lumican (show LUM Proteins) (p = 0.01) and lower expression of Decorin (show DCN Proteins) (p < 0.0001) in urothelial carcinoma of bladder
Mutation in BGN gene is associated with X-Linked Spondyloepimetaphyseal Dysplasia.
biglycan exerts an important role in cell proliferation, migration, invasion and apoptosis in colon cancer.
BGN might play an important role on metastasis in human endometrial cancer and it might be a target marker for the molecular therapy of advanced and recurrence endometrial cancer.
A novel biological pathway has been discovered of soluble biglycan inducing HIF-2alpha (show EPAS1 Proteins) protein stabilization and Epo (show EPO Proteins) production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
Results show that Bgn plays a role in the process of angiogenesis during fracture healing, and that effect appears to be partially mediated through endostatin (show COL18A1 Proteins) suppression.
Asporin (show ASPN Proteins) deficiency changes skin glycosaminoglycan composition, and decorin (show DCN Proteins) and biglycan content, which may explain the changes in skin mechanical properties.
Biglycan plays a protective role during the progression of atherosclerosis in ApoE (show APOE Proteins)-deficient mice by inhibiting thrombin (show F2 Proteins) generation.
These genes were concordantly induced by TAC (show IL2RA Proteins) in WT but not in biglycan KO mice. CONCLUSIONS: Left ventricular pressure overload induces biglycan expression in cardiac fibroblasts. Ablation of biglycan improves cardiac function and attenuates left ventricular hypertrophy and fibrosis after long-term pressure overload.
Importance of biglycan and decorin (show DCN Proteins) as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.
Biglycan deficiency leads to loosely packed aortic collagen fibers, increased susceptibility of aortic elastin (show ELN Proteins) fibers to angII-induced stress, and up-regulation of vascular perlecan (show HSPG2 Proteins) content.
Biglycan signaling supported fetal membrane remodeling during early gestation in the absence of concomitant changes in TGFbeta (show TGFB1 Proteins) levels.
Lumican (show LUM Proteins) and biglycan influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Biglycan-triggered TLR-2- and TLR-4 (show TLR4 Proteins)-signaling exacerbates the pathophysiology of ischemic acute kidney injury.
Data show that biglycan, collagen type I, collagen type II, decorin (show DCN Proteins), and versican (show Vcan Proteins) were significantly affected by vibration duration, frequency, and amplitude.
biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
The results indicate that CTGF (show CTGF Proteins) suppresses the synthesis of biglycan but newly induced that of decorin (show DCN Proteins) in the cells when the cell density is low.
LDL electrostatic interactions with decorin (show DCN Proteins) and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
Bgn regulates BMP4 (show BMP4 Proteins) signaling through modulation of Chordin (show CHRD Proteins) anti-BMP4 (show BMP4 Proteins) activity.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.
, bone/cartilage proteoglycan I
, bone/cartilage proteoglycan-I
, dermatan sulphate proteoglycan I
, small leucine-rich protein 1A
, Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)
, bone/cartilage proteclycan 1
, leucine-rich PG I