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ITIH3 rs2535629 SNP was genotyped in N=256 patients receiving various antipsychotics for up to 26weeks. Study found no association of genotype with overall changes in Brief Psychiatric Rating Scale scores, but greater improvement of negative symptoms in minor allele carriers indicates that rs2535629 may help to identify a subset of schizophrenia patients with better treatment response to clozapine.
confirmed the association of schizophrenia with ITIH3/4 in a Han Chinese population
A novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with bipolar disorder, schizophrenia and related psychosis spectrum disorders.
Study showed the association of a polymorphism (rs2535629) of ITIH3 with psychiatric disorders in an Asian population and that rs2535629 influences the susceptibility to psychiatric disorders by affecting the expression level of GLT8D1 (show GLT8D1 Proteins)
This study demonistrated that Genome-wide significant associations in schizophrenia to ITIH3/4 and extensive replication of associations reported by the Schizophrenia.
ITIH3 protein was found to be more highly expressed in plasma of tumor bearing mice compared to control.
ITIH3 single-nucleotide polymorphism is a novel genetic risk factor of myocardial infarction.
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987
ITI heavy chain H3
, inter-alpha-inhibitor H3 chain
, inter-alpha-inhibitor heavy chain 3
, inter-alpha-trypsin inhibitor heavy chain H3
, pre-alpha-inhibitor heavy chain 3
, pre-alpha-inhibitor, heavy chain 3
, inter-alpha (globulin) inhibitor H3
, inter-alpha (globulin) inhibitor, H3 polypeptide
, pre-alpha (globulin) inhibitor, H3 polypeptide
, serum-derived hyaluronan-associated protein
, Inter-alpha-inhibitor heavy chain 3