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Expression of p53 and Ki67 and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.
After intrastromal scanning of cornea, expression of Ki-67 increases.
This study demonstrated that thr Ki-67 expression was mainly observed in the olfactory bulb, rostral migratory stream, sub ventricular zone of lateral ventricle and the sub granular zone of the dentate gyrus and fewer Ki-67 positive cells were also observed in the neocortex, cerebellum and tectum.
injection of a b3-adrenergic receptor (b3-AR) agonist for continuous 5 days increased the number of Ki67-positive brown adipocytes even at Day 1 but not that of SV cells. In addition, the b3-AR antagonist, but not b1-AR antagonist, attenuated the cold exposure-induced increase in the number of Ki67-positive brown adipocytes
Ki67-positive cells are localized near inner enamel epithelium and supra-IEE, the stellate reticulum next to these is Ki67-negative. The IEE and supra-IEE contain intense Ki67-immunoreactivity, outer enamel epithelium lacks proliferative cells in mice.
Whey proteins reduced Ki-67 and 8-OHdG expression in the skin of chronically UVB-irradiated mice.
Both HDAC1 and HDAC2 play crucial roles in the regulation of liver regeneration. The loss of HDAC1/2 inhibits Ki67 expression and results in defective hepatocyte mitosis and impaired liver regeneration.
Intratumoral FLT uptake level markedly decreased at 6 h and then gradually increased with time.
Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model.
no difference in antigen expression between acute generalized exanthematous pustulosis and pustular psoriasis
The majority of tumours showed strong p16, p21, p27, pRb and cyclin D1 staining and little or no p53 expression. Tumours harbouring dysplasia were significantly more likely to be p53-positive and exhibit up-regulated p21 and p27.
Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma.
Age-related changes in proliferative markers in labial salivary glands: a study of argyrophilic nucleolar organizer regions (AgNORs) and Ki-67
the re-establishment of the cell cycle-dependent distribution of pKi-67 during early mouse development
p63 protein is essential for the embryonic development of vibrissae and teeth; while it localizes with K5 in vibrissae, it is not fully colocalized with nuclear Ki67 expression
Data show that C57BL/6 mice showed significantly higher levels of Ki-67-immunopositive cells in the subgranular zone (SGZ) of the DG compared to ICR and BALB/c mice.
Immunohistochemical staining studies show that greast tumor cells positive for ALDH1 are more likely to be Ki67 positive.
Ki-67 antigen was found to be increased by urethane, but K-ras exon 1 mutations do not play any role in the interfering effects of urethane followed by sodium nitrite and sodium chloride
For the first time coexpression of CD44 and Ki-67 on particulate thirds of crypts in neoplasms of the colon is shown and the potential reasons for this phenomenon are discussed.
he only marker clearly related to 2-year survival is Ki-67, which is shown to be a good prognostic factor in the multivariate analysis (hazard ratio = 0.49; 95% confidence interval = 0.27-0.90). Therefore, in a prospective cohort of colorectal cancer patients, only Ki-67 is a marker of good prognosis in short-term follow-up
Meta-analysis highlights Ki-67 expression as a predictor of breast ductal carcinoma in situ recurrence; nevertheless, additional adjusted studies, with adequate follow-up periods, stemming from various world regions seem to be needed on this topic.[meta-analysis]
Data suggest that Ki-67 labeling index (LI) grading of endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) specimens should be carefully applied in clinical practice because of the possibility of grading underestimation with grade 2 to 3 pancreatic neuroendocrine tumors (PanNET) cases.
Overexpression of Ki-67 is associated with recurrence in Pancreatic Neuroendocrine Tumors.
An overview of functional roles of Ki-67 across the cell cycle has been presented along with recent experiments that clarify its role in regulating cell cycle progression in human cells. (Review)
High Ki-67 expression is associated with Oral Squamous Cell Carcinoma.
Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors.
lost BMAL1 and Ki-67 overexpression are associated with poor overall survival of nasopharyngeal carcinoma patients
Low Ki-67 expression is associated with glioblastoma.
Aggressive adjuvant systemic treatments should be considered for patients with HER2-rich and triple-negative subtype who exhibit tumor shrinkage in NAC but still have high levels of Ki67.
For HR-positive, HER2-negative breast cancer patients with 0-1 node metastases, chemotherapy use declined significantly after the adoption of the 21-gene assay. PgR status and Ki-67 were useful for chemotherapy decision-making in cases without the 21-gene assay.
Suggest that different mitotic count or Ki-67 index may have different prognostic values in different stages of small intestinal neuroendocrine tumors.
DIA using VDS is an accurate method to determine the Ki67 proliferation index in breast cancer, as an alternative to manual scoring of whole sections in clinical practice.
apparent diffusion coefficient was correlated with PSA, Gleason score, and Ki-67, HIF-1alpha and VEGF expression in patients with Prostate cancer.
positive correlations were found between higher Ki-67 expression and poorer differentiation,larger tumor size and higher pathologic stages, lymph node metastasis positivity, and advanced TNM stages.
This preliminary study showed, evidently for the first time, that multiple, apparently haphazardly distributed clusters of proliferating cells are present in NDCs. Since the Ki-67 proliferation marker only labels progenitor daughter cells generated by stem cells, each MIB+ cluster in each NDC must have been produced by a single stem cell.
Studied predictive value of using mitotic count vs. Ki67 score for prediction of response to tamoxifen in postmenopausal breast cancer patients; found mitotic count is a better selection marker for reduced tamoxifen benefit than Ki67.
Ki67 LI, CD105, and alpha-SMA expression showed significant differences between normal, low-risk oral epithelial dysplasia and high-risk oral epithelial dysplasia. These findings further support that features such as increased basal cell layer hyperplasia, abnormal superficial mitosis, increased nuclear-cytoplasmic ratio, and hyperchromasia could be transformation-relevant dysplastic features.
RAGE, EGFR and Ki-67 were immunohistochemicalyl studied for their expression in biopsy specimens from primary breast tumors
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
antigen identified by monoclonal antibody Ki-67
, antigen KI-67-like
, antigen KI-67
, proliferation-related Ki-67 antigen