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Expression of p53 and Ki67 and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.
After intrastromal scanning of cornea, expression of Ki-67 increases.
This study demonstrated that thr Ki-67 expression was mainly observed in the olfactory bulb, rostral migratory stream, sub ventricular zone of lateral ventricle and the sub granular zone of the dentate gyrus and fewer Ki-67 positive cells were also observed in the neocortex, cerebellum and tectum.
injection of a b3-adrenergic receptor (b3-AR) agonist for continuous 5 days increased the number of Ki67-positive brown adipocytes even at Day 1 but not that of SV cells. In addition, the b3-AR antagonist, but not b1-AR antagonist, attenuated the cold exposure-induced increase in the number of Ki67-positive brown adipocytes
Ki67-positive cells are localized near inner enamel epithelium and supra-IEE, the stellate reticulum next to these is Ki67-negative. The IEE and supra-IEE contain intense Ki67-immunoreactivity, outer enamel epithelium lacks proliferative cells in mice.
Whey proteins reduced Ki-67 and 8-OHdG expression in the skin of chronically UVB-irradiated mice.
Both HDAC1 and HDAC2 play crucial roles in the regulation of liver regeneration. The loss of HDAC1/2 inhibits Ki67 expression and results in defective hepatocyte mitosis and impaired liver regeneration.
Intratumoral FLT uptake level markedly decreased at 6 h and then gradually increased with time.
Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model.
no difference in antigen expression between acute generalized exanthematous pustulosis and pustular psoriasis
The majority of tumours showed strong p16, p21, p27, pRb and cyclin D1 staining and little or no p53 expression. Tumours harbouring dysplasia were significantly more likely to be p53-positive and exhibit up-regulated p21 and p27.
Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma.
Age-related changes in proliferative markers in labial salivary glands: a study of argyrophilic nucleolar organizer regions (AgNORs) and Ki-67
the re-establishment of the cell cycle-dependent distribution of pKi-67 during early mouse development
p63 protein is essential for the embryonic development of vibrissae and teeth; while it localizes with K5 in vibrissae, it is not fully colocalized with nuclear Ki67 expression
Data show that C57BL/6 mice showed significantly higher levels of Ki-67-immunopositive cells in the subgranular zone (SGZ) of the DG compared to ICR and BALB/c mice.
Immunohistochemical staining studies show that greast tumor cells positive for ALDH1 are more likely to be Ki67 positive.
Ki-67 antigen was found to be increased by urethane, but K-ras exon 1 mutations do not play any role in the interfering effects of urethane followed by sodium nitrite and sodium chloride
Ki-67 and condensins, which localize to the external surface and the central axis of mitotic chromosomes, have independent yet cooperative functions in supporting the structural integrity of mitotic chromosomes.
High Ki-67 expression significantly predicts poor overall survival and disease free survival in colorectal cancer patients (meta-analysis).
The expressions of ER, PR, HER-2 and Ki-67 in metastatic lesions are associated with the prognosis of breast cancer patients.Their expression discordances between primary and metastatic lesions can guide the treatment and evaluate the risks of recurrence and prognosis.
High Ki-67 expression is associated with recurrence in papillary urothelial bladder cancer.
This is the first study to show that the Ki-67 LI in metachronous axillary lymph node metastases(ALNM) is a prognostic factor for patients with metachronous axillary lymph node (ALN) recurrence of breast cancer.
More than 20% of AR-positive cytoplasmic staining of Oral squamous cell carcinoma (OSCC) epithelium was significantly associated with nuclear AR levels in the epithelium and increased AR levels in the stroma. In metastatic OSCC patients, Ki-67 was significantly higher than in non-metastatic OSCC patients.
NMR diffusion tensor imaging has a high application value in the diagnosis of brain glioma. The expressions of Ki-67 and VEGF are related to the pathological grade of glioma, which can be used as biological indexes for the diagnosis of glioma.
BDNF and Tau as biomarkers of severity in multiple sclerosis
These results show that higher Ki67 expression in fibroblast like cells at invasive front indicated better clinical outcomes for oral squamous cell carcinoma patients.
Ki-67 may be useful diagnostic markers for carcinoma ex-pleomorphic adenoma.
In non-germinal center B-cell subtype primary central nervous system lymphoma patients, high Ki-67 index was an adverse independent prognostic marker that could be used to stratify patients for more suitable management.
not related to response to platinum-based chemotherapy, nor survival, in serous ovarian carcinoma
Positive correlations were demonstrated between the expression levels of MCM5 and the Ki-67 antigen. In vitro studies have confirmed that the expression of MCM5 is elevated in cancer cells. MCM5 protein may be used as a potential marker of cancer cell proliferation in laryngeal squamous cell cancer
Expression of Cyclin E and Ki-67 is elevated in gestational trophoblastic disease
TP53 expression (>50% positive cells) has shorter time to treatment failure and poor overall survival independent of both the Mantle Cell Lymphoma International Prognostic Index score and Ki67 index.
High value of Ki-67 is associated with Breast Carcinomas.
PR [progesterone receptor ] immunoreactive score and Ki-67 index varied widely within WHO Grade I tumours and overlapped considerably with Grade II tumours. PR expression reduced and Ki-67 index increased with increasing WHO grade (P = 0.000). A moderate inverse correlation was found between Ki-67 index and PR score (R = -0.7371).
he mean value was 12.33 +/- 21.77%. ADC correlated with weak statistical significant with expression of Ki-67 (p = - 0.202, p < 0.001). ROC analysis was performed to distinguish tumors with high proliferative potential from tumors with low expression of Ki-67 using ADC values
For the first time coexpression of CD44 and Ki-67 on particulate thirds of crypts in neoplasms of the colon is shown and the potential reasons for this phenomenon are discussed.
he only marker clearly related to 2-year survival is Ki-67, which is shown to be a good prognostic factor in the multivariate analysis (hazard ratio = 0.49; 95% confidence interval = 0.27-0.90). Therefore, in a prospective cohort of colorectal cancer patients, only Ki-67 is a marker of good prognosis in short-term follow-up
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
antigen identified by monoclonal antibody Ki-67
, antigen KI-67-like
, antigen KI-67
, proliferation-related Ki-67 antigen