Ki-67 Protein (AA 1001-1112) (His tag)

Catalog No. ABIN7505015

Product Details

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Protein Type: Recombinant

Protein Characteristics: AA 1001-1112

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Ki-67 protein is labelled with His tag.

Sequence: Lys1001-Pro1112

Characteristics: A DNA sequence encoding theHuman KI67 protein (P46013) (Lys1001-Pro1112) was expressed with a N-His.

Purity: >85 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))

Alternative Name: KI67 (MKI67 Products)

Synonyms: MKI67 Protein, kia Protein, mki67 Protein, MGC132156 Protein, D630048A14Rik Protein, Ki-67 Protein, Ki67 Protein, KIA Protein, MIB-1 Protein, marker of proliferation Ki-67 Protein, marker of proliferation Ki-67 L homeolog Protein, marker of proliferation Ki-67 S homeolog Protein, antigen identified by monoclonal antibody Ki 67 Protein, antigen identified by monoclonal antibody Ki-67 Protein, nucleolar protein interacting with the FHA domain of MKI67 Protein, MKI67 Protein, mki67 Protein, mki67.L Protein, mki67.S Protein, Mki67 Protein, NIFK Protein

Background:

Background: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly.Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface.Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility.Binds DNA, with a preference for supercoiled DNA and AT-rich DNA.Does not contribute to the internal structure of mitotic chromosomes.May play a role in chromatin organization.It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Synonym: Antigen identified by monoclonal antibody Ki-67,Antigen KI-67,Antigen Ki67

Molecular Weight: 12.4 kDa

UniProt: P46013

Pathways: Glycosaminoglycan Metabolic Process