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Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 (show ITGA3 ELISA Kits) and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5 (show LAMA5 ELISA Kits)) were significantly inhibited by curcumin at messenger RNA and protein levels.
Data suggest that, compared with obese white women, obese black women exhibit higher expression of HIF1A (hypoxia inducible factor 1 alpha (show HIF1A ELISA Kits)), COL5A1 (collagen Valpha1), and COL6A1 (show COL6A1 ELISA Kits) (collagen VIalpha1) in gluteal but not abdominal subcutaneous adipose tissue depots; up-regulation of expression of these proteins correlates with reduced insulin (show INS ELISA Kits) sensitivity in black women only.
COL5A1 mutation is associated with Adrenocortical Adenomas.
Gene expression levels of three randomly selected DEGs (show DEGS1 ELISA Kits), VCAN (show Vcan ELISA Kits), COL5A1 and KCNJ16 (show KCNJ16 ELISA Kits), were examined using RT-PCR in 10 ATC (show SRPK1 ELISA Kits) samples.. angiogenesis was activated by the high expression of CTHRC1 (show CTHRC1 ELISA Kits), VCAN (show Vcan ELISA Kits) and POSTN (show POSTN ELISA Kits), providing necessary nutrition for tumor cells
COL5A1 rs12722 was found to be associated with severity of musculoskeletal injuries but not with incidence of musculoskeletal injuries in top-level soccer players.
Data (including data from studies in knockout mice) suggest causative role for collagen(V)alpha1 hypersensitivity/autoimmunity in pathogenesis of atherosclerosis; both immune tolerance and reduction of plaque burden are dependent on interleukin 35.
Familial Ehlers-Danlos syndrome with lethal arterial events caused by a mutation in COL5A1 is described in a mother and her two sons, who all died at an early age from arterial ruptures.
Individuals with the BstUI A1 allele and DpnII B2 allele of the COL5A1 gene have a high likelihood of developing symptoms of the tennis elbow
In conclusion, the novel main finding of this study was a significant interaction between the COL5A1 rs12722 T/C and COL12A1 (show COL12A1 ELISA Kits) rs970547 A/G variants and risk of anterior cruciate ligament injury.
variants within the functional COL5A1 3'-untranslated region are associated with idiopathic carpal tunnel syndrome
Significantly decreased fibroblast proliferation was observed in Col5a1(+/-) compared to Col5a1(+/+) fibroblasts.
Col5a1 knockout stroma demonstrated severe dysfunctional regulation of fibrillogenesis.
Sp7/Osterix (show SP7 ELISA Kits) was observed to participate in the activation of the Col5a1 promoter during osteoblast differentiation.
Col (show HDAC1 ELISA Kits)(V) is an established autoantigen in atherosclerotic mice, and Col (show HDAC1 ELISA Kits)(V) autoimmunity is a consistent feature, with variable T helper type (Th)1 (show TH1L ELISA Kits) cell pathway involvement.
analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V (show COL5A3 ELISA Kits)) procollagen heterotrimer
CBF (show CEBPZ ELISA Kits) activated the Col5a1 promoter suggesting that CBF (show CEBPZ ELISA Kits) is a key factor in the coordinated expression of type I and V collagen genes
COL5A1 is regulated by TGF-beta (show TGFB1 ELISA Kits) in osteoblasts
col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages
Type V collagen contributes to the development of functional connective tissues during embryogenesis.
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
collagen alpha-1(V) chain
, collagen type 5 alpha 1
, procollagen alpha 1(V)
, alpha 1 (V) collagen
, alpha-1(V) collagen
, type V collagen
, collagen, type V, alpha 1
, alpha-1 type V collagen
, alpha1(V) collagen
, pro-alpha1(V) collagen
, procollagen type V alpha 1
, procollagen, type V, alpha 1
, collagen alpha 1 (V)