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anti-Mouse (Murine) ESM1 Antibodies:
anti-Rat (Rattus) ESM1 Antibodies:
anti-Human ESM1 Antibodies:
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Human Monoclonal ESM1 Primary Antibody for IHC (p), ELISA - ABIN564812
Liu, Zhang, Du, Hu, Zhang, Wang, Li, Ji: Overexpression of endothelial cell specific molecule-1 (ESM-1) in gastric cancer. in Annals of surgical oncology 2010
Show all 3 Pubmed References
Rat (Rattus) Polyclonal ESM1 Primary Antibody for ICC, IHC - ABIN1175699
Zhao, Xue, Guo, Sun, Liu, Wang: Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension. in International immunopharmacology 2016
Data from murine model indicate that NGFR plays an important role in the pathogenesis and progression of oral squamous cell carcinoma via regulation of ESM1.
glomerular-derived Esm-1 as a potential non-invasive biomarker of diabetic nephropathy
Results reveal a novel pathway for endocan in the control of tumor growth, which involves inflammatory cells of the innate immunity.
Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis.
endocan is normally present in the mouse brain and prior vascular perfusion with FITC may provide a useful tool for identify newly forming blood vessels.
Mouse endocan serum level was measured at a median of 0.96 ng/mL and 1.08 ng/mL in 129Sv mice and C57bl6, respectively.
A paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor.
Results suggest that endocan (ESM-1)is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors.
ESM-1 is significantly upregulated by the HIF-1alpha/VEGF pathway under intermittent hypoxia in endothelial cells, playing a critical role in enhancing adhesion between monocytes and endothelial cells.
Endocan values were not significantly correlated with the duration of CPB.
Further studies should investigate the prognostic value of the magnitude of postoperative Endocan concentration after cardiac surgery.
endocan values of less than 2.54ng/mL may be predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock
serum levels were significantly lower in liver cirrhosis patients with cirrhotic cardiomyopathy
the results of the present study showed that the knockdown of ENDOCAN inhibited cell growth and induced cell apoptosis, which was accompanied by the inhibition of NF-kappaB activity in myeloid leukemia cells, indicating that ENDOCAN is a promising therapeutic target in leukemia.
serum pro-BNP and endocan levels were increased in hemodynamically significant patent ductus arteriosus infants before medical treatment and decreased in the days followed appropriate treatment
Serum endocan level shows a correlation with deteriorated aortic elastic properties, and could b a surrogate marker of escalating aortic stiffness in patients with newly diagnosed essential hypertension.
high Endocan level is associated with poor lung functions and severity of asthma in children
Blood endocan level is increased in polycystic ovary syndrome.
Study found significant differences in median (interquartile) endocan serum level in women with intrauterine growth restriction (IUGR) and control groups Endocan is likely involved in the pathogenesis of IUGR in pregnant women and possibly is a useful marker of endothelial dysfunction in these cases.
Elevated circulating endocan levels are associated with reduced lung ventilation function in COPD patients and those with acute exacerbation of COPD.
Endocan levels were associated with the development of Ventilator-Associated Pneumonia.
Serum endocan can correlate with erectile dysfunction (ED) severity and carotid intima-media thickness. In addition, it has a predictive value for cardiovascular risk in ED patients.
endocan levels are higher in patients who require mechanical ventilation in severe sepsis
Results show that aerum ESM-1 levels were significantly higher in the idiopathic sudden sensorineural hearing loss group than the control group which may confirm endothelial dysfunction involvement.
suggest that measurement of endocan level may help clinicians to predict the development of coronary collateral circulation in patients with stable coronary artery disease
suggest that serum ESM-1 level may be a novel endothelial dysfunction biomarker
Plasma ESM-1 levels are decreased during pregnancy and increased in early- and late-onset preeclampsia. The source of ESM-1 is probably not the placenta, but most likely maternal endothelial cells.
Serial endocan concentration meets the major requirements for predicting outcome in patients with severe sepsis. An assay of endocan concentration may be a good prognostic biomarker in the clinic for severe sepsis.
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.
endothelial cell-specific molecule 1
, ESM-1 secretory protein
, pineal specific PG25 protein