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anti-Mouse (Murine) ESM1 Antibodies:
anti-Rat (Rattus) ESM1 Antibodies:
anti-Human ESM1 Antibodies:
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Human Monoclonal ESM1 Primary Antibody for IHC (p), ELISA - ABIN564812
Liu, Zhang, Du, Hu, Zhang, Wang, Li, Ji: Overexpression of endothelial cell specific molecule-1 (ESM-1) in gastric cancer. in Annals of surgical oncology 2010
Show all 3 Pubmed References
Rat (Rattus) Polyclonal ESM1 Primary Antibody for ICC, IHC - ABIN1175699
Zhao, Xue, Guo, Sun, Liu, Wang: Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension. in International immunopharmacology 2016
Data from murine model indicate that NGFR (show NGFR Antibodies) plays an important role in the pathogenesis and progression of oral squamous cell carcinoma via regulation of ESM1.
glomerular-derived Esm-1 as a potential non-invasive biomarker of diabetic nephropathy
Results reveal a novel pathway for endocan in the control of tumor growth, which involves inflammatory cells of the innate immunity.
Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF (show VEGFA Antibodies) bioavailability.
This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis.
endocan is normally present in the mouse brain and prior vascular perfusion with FITC may provide a useful tool for identify newly forming blood vessels.
Mouse endocan serum level was measured at a median of 0.96 ng/mL and 1.08 ng/mL in 129Sv mice and C57bl6, respectively.
A paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 (show EDN1 Antibodies) acting on the vascular smooth muscle ET(A (show EDNRA Antibodies)) receptor.
Results suggest that endocan (ESM-1)is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors.
Studied serum endocan levels in endometrial and ovarian cancer. Serum endocan levels were significantly higher in the entire patient group than in the controls.
This study showed that ESM-1 level in pleural effusion could be a potential diagnostic and prognostic marker in NSCLC patients with MPE.
Severe erectile dysfunction was associated with higher serum endocan levels than less severe erectile dysfunction or healthy controls.
Serum endocan levels >/= 2.05 ng/ml had a sensitivity of 76.1% and specificity of 85% for the diagnosis of bacterial infection in decompensated cirrhotic patients. The endocan measured at admission is a good clinical parameter predicting the occurrence of infection in these patients. Elevated endocan may reflect the degree of endothelial cell injury by a systemic inflammatory response.
study showed that higher endocan levels were significantly and independently related to the presence of slow coronary flow.
The results suggest that endocan may have a role in the pathogenesis of pterygium.
Endocan expression is increased in the human placenta from obese women with gestational diabetes, and in response to pro-inflammatory stimuli. Loss-of-function studies in villous trophoblast cells and HUVECs revealed that endocan is not directly involved in the genesis or in the expression of pro-inflammatory cytokines induced by LPS (show IRF6 Antibodies) or IL-1beta (show IL1B Antibodies).
Systemic inflammation may be responsible for the rise in endocan levels following cardiopulmonary bypass.
Endocan expression was correlated with poor clinical outcomes in patients with Pancreatic Neuroendocrine Tumors . The results indicated that endocan expression may be a reliable marker for predicting tumor recurrence in patients with PNETs.
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.
endothelial cell-specific molecule 1
, ESM-1 secretory protein
, pineal specific PG25 protein