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Study shows that WISP1 expression is significantly upregulated in glioblastoma tissue and cell lines. Also, WISP1 seems to be an important regulator of glioblastoma cell proliferation, apoptosis, migration, invasion, and TMZ drug resistance. WISP1 mediates these biological processes through regulating critical gene expression and pathways that are involved in cancer progression.
WISP1 has a role in colon cancer apoptosis, invasion and poor prognosis
Results indicate that SFRP1 (show SFRP1 Proteins) rs7832767 C > T, CTNNB1 (show CTNNB1 Proteins) rs2293303 C > T, and WISP1 rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
There is a relationship between WISP1 and the metabolic parameters of gestational diabetes (GDM). And, WISP1 might be involved in the pathophysiology of GDM.
Macrophage-derived IL-10 (show IL10 Proteins) has a role in mediating mucosal repair by epithelial WISP-1 signaling
results demonstrate that a joint effect of WISP1 rs2929970 with smoking as well as WISP1 rs16893344 with betel nut chewing causally contributes to the occurrence of OSCC. WISP1 polymorphism may serve as a marker or a therapeutic target in OSCC
Taken together, our findings presented the first evidence that Wnt1-inducible signaling pathway protein-1 was upregulated in gastric cancer and acted as an oncogene (show RAB1A Proteins) by promoting proliferation, migration, and invasion in gastric cancer cells.
findings reveal that WISP-1 enhances VEGF-A (show VEGFA Proteins) expression and angiogenesis through the FAK (show PTK2 Proteins)/JNK (show MAPK8 Proteins)/HIF-1alpha (show HIF1A Proteins) signaling pathways, as well as via down-regulation of miR (show MLXIP Proteins)-381 expression.
Akt (show AKT1 Proteins) signaling pathway mediates WISP1-induced migration and proliferation of human VSMCs
WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut (show GUSB Proteins).
Two paralogs of mammalian wisp1 genes were found in zebrafish.
WISP1 plays an aggravating role in the development of post-traumatic experimental OA.
Data revealed that reconstituted overexpression of WISP-1 could largely reverse the Notch1 (show NOTCH1 Proteins)-/--induced metastasis-promoting effect of mesenchymal stem cell-derived stromal fibroblasts (MSC (show MSC Proteins)-DF); thus, demonstrating that the Notch1 (show NOTCH1 Proteins)-determined melanoma metastasis-regulating role of MSC (show MSC Proteins)-DF is mediated primarily by WISP-1.
Upregulation of Wnt2 (show WNT2 Proteins) expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4 (show TLR4 Proteins)/TRIF (show RNF138 Proteins) signaling.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3 (show TGFB3 Proteins).
the Bmp3 (show BMP3 Proteins)/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
WISP1 is a novel regulator of bone turnover and Wnt (show WNT2 Proteins) signaling
The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin (show INS Proteins) resistance and could be a novel therapeutic target for obesity.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
CCN family member 4
, WNT1 induced secreted protein 1
, WNT1-inducible-signaling pathway protein 1
, Wnt-1 inducible signaling pathway protein 1
, Wnt-1-induced secreted protein
, WNT1 inducible signaling pathway protein 1