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Two paralogs of mammalian wisp1 genes were found in zebrafish.
WISP1 has a role in colon cancer apoptosis, invasion and poor prognosis
Results indicate that SFRP1 (show SFRP1 Proteins) rs7832767 C > T, CTNNB1 (show CTNNB1 Proteins) rs2293303 C > T, and WISP1 rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
There is a relationship between WISP1 and the metabolic parameters of gestational diabetes (GDM). And, WISP1 might be involved in the pathophysiology of GDM.
Macrophage-derived IL-10 (show IL10 Proteins) has a role in mediating mucosal repair by epithelial WISP-1 signaling
results demonstrate that a joint effect of WISP1 rs2929970 with smoking as well as WISP1 rs16893344 with betel nut chewing causally contributes to the occurrence of OSCC. WISP1 polymorphism may serve as a marker or a therapeutic target in OSCC
Taken together, our findings presented the first evidence that Wnt1-inducible signaling pathway protein-1 was upregulated in gastric cancer and acted as an oncogene (show RAB1A Proteins) by promoting proliferation, migration, and invasion in gastric cancer cells.
findings reveal that WISP-1 enhances VEGF-A (show VEGFA Proteins) expression and angiogenesis through the FAK (show PTK2 Proteins)/JNK (show MAPK8 Proteins)/HIF-1alpha (show HIF1A Proteins) signaling pathways, as well as via down-regulation of miR (show MLXIP Proteins)-381 expression.
Akt (show AKT1 Proteins) signaling pathway mediates WISP1-induced migration and proliferation of human VSMCs
WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut (show GUSB Proteins).
Data show that WNT1-inducible signaling pathway protein-1 (WISP)-1/CCN4 expression was correlated with vascular endothelial growth factor-C (VEGF-C (show VEGFC Proteins)) expression in Oral squamous cell carcinoma (OSCC) specimens.
Data revealed that reconstituted overexpression of WISP-1 could largely reverse the Notch1 (show NOTCH1 Proteins)-/--induced metastasis-promoting effect of mesenchymal stem cell-derived stromal fibroblasts (MSC (show MSC Proteins)-DF); thus, demonstrating that the Notch1 (show NOTCH1 Proteins)-determined melanoma metastasis-regulating role of MSC (show MSC Proteins)-DF is mediated primarily by WISP-1.
Upregulation of Wnt2 (show WNT2 Proteins) expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4 (show TLR4 Proteins)/TRIF (show RNF138 Proteins) signaling.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3 (show TGFB3 Proteins).
the Bmp3 (show BMP3 Proteins)/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
WISP1 is a novel regulator of bone turnover and Wnt (show WNT2 Proteins) signaling
The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin (show INS Proteins) resistance and could be a novel therapeutic target for obesity.
Wnt5a (show WNT5A Proteins)-induced Wnt1 (show WNT1 Proteins)-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
WNT1 inducible signaling pathway protein 1
, CCN family member 4
, WNT1 induced secreted protein 1
, WNT1-inducible-signaling pathway protein 1
, Wnt-1 inducible signaling pathway protein 1
, Wnt-1-induced secreted protein