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anti-Human WISP2 Antibodies:
anti-Mouse (Murine) WISP2 Antibodies:
anti-Rat (Rattus) WISP2 Antibodies:
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Human Polyclonal WISP2 Primary Antibody for IP, WB - ABIN948739
Conde, Scotece, Abella, Gómez, López, Villar, Hermida, Pino, Gómez-Reino, Gualillo: Identification of novel adipokines in the joint. Differential expression in healthy and osteoarthritis tissues. in PLoS ONE 2015
Human Polyclonal WISP2 Primary Antibody for IHC (p), WB - ABIN390188
Kumar, Hand, Connor, Dodds, Ryan, Trill, Fisher, Nuttall, Lipshutz, Zou, Hwang, Votta, James, Rieman, Gowen, Lee: Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. in The Journal of biological chemistry 1999
Show all 3 Pubmed References
One paralog of mammalian wisp2 was found in zebrafish.
The authors show that, in triple-negative-breast cancer (TNBC) cells enriched with tumor initiating cells, CCN5 significantly blocks cellular growth via apoptosis, reversing epithelial-mesenchymal-transition-signaling and impairing mammosphere formation, thereby blocking the tumor-forming ability and invasive capacity of these cells.
by analyzing different estrogen receptor-alpha(ER-a (show ESR1 Antibodies))-positive and ER-a (show ESR1 Antibodies)-negative breast cancer cell lines, we defined the role of CCN5 in the leptin (show LEP Antibodies)-mediated regulation of growth and invasive capacity.
CCN3 (Nov (show NOV Antibodies)) and CCN5 (WISP2) are novel substrates of MMP14 (show MMP14 Antibodies).
Results show that WISP2 and beta-catenin (show CTNNB1 Antibodies) were more highly expressed in gastric cancer tissues and seem to correlate with early stage or without metastasis.
Studies indicate that the CYR61 (show CYR61 Antibodies) CTGF (show CTGF Antibodies) NOV (show NOV Antibodies) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Antibodies), CCN2 (show CTGF Antibodies), CCN3 (show NOV Antibodies), CCN4 (show WISP1 Antibodies), CCN5 and CCN6 (show WISP3 Antibodies) and have been identified in various types of cancer.
Report opposing effects of CCN2 (show CTGF Antibodies) and CCN5 on fibroblast proliferation and transdifferentiation induced by TGF-beta (show TGFB1 Antibodies).
Serum WISP2 correlated directly with fatty acid binding protein 4. Serum SFRP5 (show SFRP5 Antibodies) did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (show SFRP5 Antibodies) (p<5x10(-6) as compared to both PCOS groups).
Activation of CCN5 may have the therapeutic potential to kill triple-negative breast cancer.
WISP2 has a role in regulating tumor cell susceptibility through EMT (show ITK Antibodies) by inducing the TGF-beta (show TGFB1 Antibodies) signaling pathway, KLF-4 (show KLF4 Antibodies) expression and miR-7 (show LILRB1 Antibodies) inhibition.
overexpression of FGFBP1 (show FGFBP1 Antibodies) or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.
Insulin (show INS Antibodies)-like growth factor (IGF)-1 (show IGF1 Antibodies) elicited clear stimulation of WNT1 inducible signaling pathway protein 2 (CCN5/WISP2) mRNA and protein levels in cultured islets.
Data suggest that CCN5, minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1 (insulin-like growth factor I (show IGF1 Antibodies)); overexpression of CCN5 stimulates cell proliferation and inhibits streptozotocin-induced apoptosis.
These results suggested that secreted Wisp2/CCN5 induces Akt (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) phosphorylation via integrins, and consequently facilitates neurite formation and conferred resistance to apoptosis.
CCN2 (show CTGF Antibodies) is pro-hypertrophic and -fibrotic, whereas CCN5 is anti-hypertrophic and -fibrotic.
Although WISP-2 is a downstream protein of Wnt (show WNT2 Antibodies) signaling, the role of WISP-2 on adipocyte differentiation may be marginal, at least in this in vitro culture model.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
WNT1 inducible signaling pathway protein 2
, Wnt-1 inducible-signaling pathway protein 2
, WNT1 inducible signaling pathway 2
, CCN family member 5
, WNT1-inducible-signaling pathway protein 2
, connective tissue growth factor-like protein
, connective tissue growth factor-related protein 58
, wnt-1 signaling pathway protein 2
, CCN family protein COP-1