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WISP-3/CCN6 has a role in inhibiting apoptosis by regulating caspase (show CASP3 Proteins) pathway after hyperoxia in lung epithelial cells
WISP3 gene was associated with developmental dysplasia of the hip (DDH (show DDH Proteins)) in Chinese Han population. GGCGG haplotype might be a biomarker for DDH (show DDH Proteins).
analysis of WISP3 mutations causing progressive pseudorheumatoid dysplasia in Jammu and Kashmir-India
we found that WISP-3 induced VEGF-A (show VEGFA Proteins) expression and subsequently promoted angiogenesis and tumor growth in human chondrosarcoma cells via suppressing miR (show MLXIP Proteins)-452 through the c-Src (show SRC Proteins) and p38 (show CRK Proteins) signaling cascades.
These results demonstrate that CCN6 regulates epithelial and mesenchymal states transition and tumor initiating cells programs in breast cancer
two WISP3 mutations have been identified in two affected siblings by targeted NGS, thus permitting the clinical diagnosis of PPD (show HPD Proteins). This case supports the utility of NGS in the genetic characterization of skeletal dysplasias, which in turn may aid their clinical care, permit predictive screening, and to provide genetic counselling to families.
CCN6 acts as a molecular brake, which is appropriately balanced by Nrf2 (show GABPA Proteins), in regulating mitochondrial function.
Studies indicate that the CYR61 (show CYR61 Proteins) CTGF (show CTGF Proteins) NOV (show NOV Proteins) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Proteins), CCN2 (show CTGF Proteins), CCN3 (show NOV Proteins), CCN4 (show WISP1 Proteins), CCN5 (show WISP2 Proteins) and CCN6 and have been identified in various types of cancer.
WISP3 harbored not only frameshift mutation but also mutational intratumoral heterogeneity and loss of expression, which together might play a role in tumorigenesis of GC and CRC (show CALR Proteins) with MSI (show MSI1 Proteins)-H by inhibiting tumor suppressor functions of WISP3.
WISP3 variant leads to the diagnosis of SEDT (show TRAPPC2 Proteins)-PA.
demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK (show PTK2 Proteins)(Y397).
the WISP3 gene is essential to skeletal growth or homeostasis in humans but not in mice [WISP3]
One paralog of mammalian wisp3 was found in zebrafish.
Overexpression of zebrafish Wisp3 protein inhibited bone morphogenetic protein (BMP) and Wnt signaling in developing zebrafish.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene.
CCN family member 6
, WNT1-inducible-signaling pathway protein 3
, WNT1 inducible signaling pathway protein 3
, WNT1-inducible-signaling pathway protein 3-like