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The mechanism by which GLI1 loss of function sensitized tumor cells to vorinostat-induced apoptosis is at least in part through interactions with vorinostat to alter gene expression in a manner that favored apoptosis.
these findings propose that A3AR (show ADORA3 Proteins) agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 and GLI-1 cascade.
Gli1 could be a stem cell marker and an indicator of poor prognosis in patients with ductal breast carcinoma.
Expression of SHH (show SHH Proteins) and GLI1 may be useful prognostic markers of Merkel cell carcinoma because increased expression was associated with better prognosis. Report high rate of silent mutations in GLI1 exon 5.
Results show that Gli1 and FoxM1 (show FOXM1 Proteins) expression levels are consistently elevated in human colorectal cancer (CRC (show CALR Proteins)) tissues. Moreover, Gli1 regulates the transcription of FoxM1 (show FOXM1 Proteins) by directly binding to the promoter of FoxM1 (show FOXM1 Proteins), which contributes to the proliferation of CRC (show CALR Proteins) cells.
Results found that GLI1 expression is regulated by GAL1 (show LGALS1 Proteins) in gastric cancer tissue specimen and cell lines.
Results indicated that GLI1 activation in TN-IBC as in TNBC, plays a vital role in promoting cell proliferation, motility, tumor growth, and formation of tumor emboli.
High gli1 expression is associated with Small Cell Lung Cancer.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (show KRT17 Proteins) expression. In the KRT17 (show KRT17 Proteins)-positive regions in OSCCs, GLI-1 or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 (show CASP3 Proteins) positive was decreased. CONCLUSIONS: KRT17 (show KRT17 Proteins) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (show KRT17 Proteins) overexpression by GLIs in OSCC
Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF (show MITF Proteins).
Data indicate that the expression levels of transcription factors Gli1 and Gli2 in muscle were the lowest of the 13 tissues.
Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (show ZYX Proteins) inhibits Shh (show SHH Proteins) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
Mutation of hmgcs1 (show HMGCS1 Proteins) had no effect on Shh (show SHH Proteins) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh (show SHH Proteins) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 Proteins) mutants.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 Proteins) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Proteins)) factor activity.
Shh (show SHH Proteins) production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model.
USP21 (show USP21 Proteins) recruits and stabilises Gli1 at the centrosome.
High Gli1 expression is associated with leukemia.
Sufu (show SUFUH Proteins) is upregulated in active Shh (show SHH Proteins) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
NANOG (show NANOG Proteins) binds to GLI1 and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.
characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog (show SHH Proteins) pathway
the three GLI factors(GLI1, GLI2, and GLI3 (show GLI3 Proteins)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5