Browse our Indian Hedgehog Proteins (IHH)

Human Indian Hedgehog (IHH) interaction partners

1. Studies suggest significance of other signaling aside from hedgehog (show SHH Proteins) in the pathogenesis of basal cell carcinoma (BCC) of the skin.

2. Gorlin syndrome-derived induced pluripotent stem cells (iPSCs) expressed lower basal levels than control iPSCs of the genes encoding the Hh ligands Indian Hedgehog (IHH) and Sonic Hedgehog (SHH (show SHH Proteins)).

3. Hedgehog (show SHH Proteins) pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 (show GLI1 Proteins) inhibitors.

4. CLIC4 (show CLIC4 Proteins) and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.

5. The serum levels of IHH and SHH (show SHH Proteins) were significantly higher in autistic subjects than those of control subjects. The findings support a correlation between SHH (show SHH Proteins), IHH and BDNF (show BDNF Proteins) in autistic children, suggesting their pathological role in autism.

6. Our results show for the first time that Indian hedgehog does not cause extracellular matrix degradation in healthy ex vivo cartilage or in the presence of IL-1beta (show IL1B Proteins)

7. The Annexin a2 (show ANXA2 Proteins) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH Proteins) Pathway.

8. Studies indicate that the hedgehog (show SHH Proteins) (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.

9. Findings demonstrated that Ihh promotes human cartilage endplate degeneration.

10. endogenously produced IHH is playing a critical role in regulating hBMSC chondrogenesis.

Mouse (Murine) Indian Hedgehog (IHH) interaction partners

1. loss of Spop (show SPOP Proteins), but not Spopl (show SPOPL Proteins), disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop (show SPOP Proteins)-mediated protein degradation in mouse skeletal development; overexpressed Spop (show SPOP Proteins) targets both Gli3FL (show GLI3 Proteins) and Gli3R for ubiquitination and degradation and Spop (show SPOP Proteins) is an important positive regulator of Ihh signaling and skeletal development

2. Ihh is regulated by at least 9 enhancers with individual tissue specificities in the digit anlagen, growth plates, skull sutures and fingertips. Consecutive deletions, resulting in growth defects of the skull and long bones, showed that these enhancers function in an additive manner. Duplications caused dose-dependent upregulation and misexpression of Ihh, abnormal phalanges, fusion of sutures and syndactyly.

3. GPC6 (show GPC6 Proteins) stimulates Hh signaling by binding to Hh and Ptc1 (show PTCH1 Proteins) at the cilium and increasing the interaction of the receptor and ligand to promote the growth of developing long bones.

4. An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col (show HDAC1 Proteins) IX -/- mice and, as a result, to the early onset of disc degeneration.

5. findings thus demonstrate that augmented Ihh signaling is detrimental to craniofacial development, and that finely tuned Ihh signaling is critical for temporomandibular joint formation.

6. Ihh has an important role in regulating limb mesenchymal cell differentiation

7. Ihh and PTH1R (show PTH1R Proteins) signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.

8. The Annexin a2 (show ANXA2 Proteins) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH Proteins) Pathway.

9. Ihh expression was downregulated in femur epiphyses of Hand1 (show HAND1 Proteins)-overexpressing mice. Hand1 (show HAND1 Proteins) downregulated Ihh gene expression in vitro by inhibiting Runx2 (show RUNX2 Proteins) transactivation of the Ihh proximal promoter.

10. In organogenesis of the ovary, production of Dhh (show DHH Proteins)/Ihh in granulosa cells requires growth differentiation factor 9 (show GDF9 Proteins) from the oocyte.

Xenopus laevis Indian Hedgehog (IHH) interaction partners

1. By a combination of embryological andmolecular approaches the results demonstrated that Indian hedgehog protein signaling drives the migration of neural crest cells by autocrine or paracrine mechanisms.

2. Considered collectively, the present study suggests that X-bhh evolutionally acquired the function to induce osteogenesis; however, the expression profile of X-bhh in epiphysis is related to the late development of endochondral ossification in X. laevis.

Zebrafish Indian Hedgehog (IHH) interaction partners

1. Data indicate that SRY-box containing gene 4 protein (Sox4) is required to limit the extent of Hedgehog (show SHH Proteins) (Hh) signaling during eye development.

2. Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent patterning

3. Data showe that hedgehog (Hh) signaling regulates the expression of pth2 transcripts.