Browse our anti-Claudin 4 (CLDN4) Antibodies

Human Claudin 4 (CLDN4) interaction partners

1. expression of claudin-4 is highly specific for true epithelial differentiation and may be useful to distinguish SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex-deficient undifferentiated carcinomas from sarcomas with epithelioid morphology. The lack of claudin-4 expression in ovarian small cell carcinomas of hypercalcemic type suggests that these tumors may be better regarded as sarcomas rather than carcinomas.

2. Data indiate a regulatory network in gastric cancer whereby claudin-4 expression is reduced by specific miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), resulting in increased claudin-4 expression.

3. This is the first study to show how TGF-beta (show TGFB1 Antibodies) regulates the expression of Claudin-4 through c-Jun (show JUN Antibodies) signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.

4. Claudin-4 functionally contributes to both ovarian tumor cell apoptosis resistance and migration and targeting extracellular loop interactions of claudin-4 may have therapeutic implications for reducing ovarian tumor burden.

5. Fluorescence-based flow cytometry and xenon magnetic resonance imaging (MRI (show C7ORF49 Antibodies)) indicate binding of the biosensor specifically to claudin 4 (Cldn4)-expressing cells.

6. Studies indicate that Grainyhead-like transcription factor 2 (show HNF1B Antibodies) (GRHL2 (show GRHL2 Antibodies)) controls the expression of E-cadherin (CDH1 (show CDH1 Antibodies)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4) in tight junctions.

7. Studies indicate claudin 1 (CLDN-1 (show CLDN1 Antibodies)) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics.

8. Mislocalization claudin-3 (show CLDN3 Antibodies) to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.

9. Reg (show EXTL3 Antibodies) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.

10. claudin-4 may represent different mechanisms of lymphatic vessel invasion with both biomarkers is related to poor prognosis

Mouse (Murine) Claudin 4 (CLDN4) interaction partners

1. Reg (show KCNH2 Antibodies) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.

2. a Grhl2 (show GRHL2 Antibodies)/Ovol2 (show OVOL2 Antibodies) network controls Cldn4 and Rab25 (show RAB25 Antibodies) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

3. Data show that claudin-4 and claudin-7 (show CLDN7 Antibodies) were observed in hepatocytes of severely damaged mouse and human livers.

4. The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (show PRSS8 Antibodies)).

5. Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.

6. The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.

7. the results indicate that Grhl2 (show GRHL2 Antibodies) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Antibodies) and Cldn4, as well as of Rab25 (show RAB25 Antibodies), which increases the Cldn4 protein and its localization at TJs

8. Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (show CLDN3 Antibodies)/-4 protein suggests structural modifications of the toxin to target specific claudins

9. Claudin-3 (show CLDN3 Antibodies) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes

10. Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.

Pig (Porcine) Claudin 4 (CLDN4) interaction partners

1. Tumor necrosis factor-alpha (show TNF Antibodies) increases claudin-1 (show CLDN1 Antibodies), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.

2. Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells

3. These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.