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anti-Mouse (Murine) EIF2AK1 Antibodies:
anti-Rat (Rattus) EIF2AK1 Antibodies:
anti-Human EIF2AK1 Antibodies:
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HRI mediates the cellular confinement and killing of virulent L. monocytogenes.
heme-regulated inhibitor (HRI), protein kinase (show CDK7 Antibodies) R (PKR (show EIF2AK2 Antibodies)), PKR (show EIF2AK2 Antibodies)-like endoplasmic reticulum kinase, (PERK (show EIF2AK3 Antibodies)) and general control non-depressible 2 (GCN2 (show EIF2AK4 Antibodies)) are sufficient for the integrated stress response; there are no additional eIF2alpha (show EIF2A Antibodies) kinases in vertebrates
Heme-Regulated eIF2alpha (show EIF2A Antibodies) Kinase Modulates Hepatic FGF21 (show FGF21 Antibodies) and Is Activated by PPARbeta (show PPARD Antibodies)/delta Deficiency. Findings suggest that HRI is a potential target for regulating hepatic FGF21 (show FGF21 Antibodies) levels.
These findings indicate that the anti-proliferative actions of PKR (show EIF2AK2 Antibodies) on pancreatic beta-cells may contribute to the pathogenesis of type 2 diabetes.
eukaryotic initiation factor 2alpha kinase is a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.
HRI has an essential role in mediating arsenite stress-induced phosphorylation of eukaryotic translation initiation factor 2alpha (show EIF2S1 Antibodies), inhibition of protein synthesis, stress granule formation, and survival
Study of the kinetics showed that the heme-regulated inhibitor (HRI) kinase reaction follows classical Michaelis-Menten kinetics with respect to ATP but sigmoidal kinetics and positive cooperativity with respect to the protein substrate.
Results demonstrate that heme-regulated eIF2alpha (show EIF2A Antibodies) kinase deficiency attenuates hepcidin (show HAMP Antibodies) expression and iron homeostasis in mice, indicating a potential role for HRI in the anemia of inflammation.
heme-regulated eIF2alpha (show EIF2A Antibodies) kinase deficiency exacerbates decreases in hepcidin (show HAMP Antibodies) expression and splenic macrophage iron in HFE (show HFE Antibodies)(-)(/)(-) mice
The anti-viral properties of eIF2alpha (show EIF2A Antibodies) kinases are not always related to their inhibitory effects on host protein synthesis as previously thought and are possibly mediated by phosphorylation of proteins other than eIF2alpha (show EIF2A Antibodies).
Taken together, these results suggest HRI as a potential therapeutic target for hemoglobinopathies.
data suggests that glutamatergic stimulation induces HRI activation by NO to trigger GluN2B (show GRIN2B Antibodies) expression and this process would be relevant to maintain postsynaptic activity in cortical neurons
The antiviral kinase PKR (show PKLR Antibodies) plays a critical role in controlling HCMV replication.
structural and functional stability of HRI
Infection-associated functions of HRI (an eIF2alpha (show EIF2A Antibodies) kinase) are independent of its activity as a regulator of protein synthesis.
During lead-stress, the regulation of hHRI mRNA translation is mediated through its 5'-untranslated region (UTR (show UTS2R Antibodies)) that interacts with specific trans-acting factors.
Dephosphorylation of eIF2alpha (show EIF2A Antibodies), specifically in the cortex, is both correlated with and necessary for normal memory consolidation.
autophosphorylation of Thr485 is essential for the hyperphosphorylation and activation of HRI and is required for the acquisition of the eIF2alpha (show EIF2A Antibodies) kinase activity
the inherent structural stability of HRI (KD)
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.
eukaryotic translation initiation factor 2-alpha kinase 1
, eukaryotic translation initiation factor 2 alpha kinase 1
, eIF 2a kinase
, heme-controlled repressor
, heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
, heme-regulated inhibitor
, hemin-sensitive initiation factor 2-alpha kinase
, hemin-sensitive initiation factor 2a kinase
, heme regulated initiation factor 2 alpha kinase
, heme sensitive initiation factor 2a kinase
, heme-regulated initiation factor 2-alpha kinase
, heme-regulated repressor
, eukaryotic initiation factor 2 alpha kinase
, heme-regulated eIF-2a kinase