anti-OAS1B Antibodies

Protein Summary

This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product.

Alternative names and synonyms associated with OAS1B

• 2'-5' oligoadenylate synthetase 1B (Oas1b) antibody
• 2-5 oligoadenylate synthetase 1B (Oas1b) antibody

• (2-5')oligo(A) synthase 1B antibody
• 2-5A synthase 1B antibody
• Flv antibody
• L1 antibody
• Mmu-L1 antibody
• Show all synonym aliases
• Oas1 antibody
• Oias-2 antibody
• Oias2 antibody
• Wnv antibody

Protein level used designations for OAS1B

(2-5')oligo(A) synthase 1B , (2-5')oligo(A) synthetase 1b , 2',5'-oligoadenylate synthetase-like 1 , 2'-5'-oligoadenylate synthase 1B , 2'-5'-oligoadenylate synthase-like protein 1 , 2'-5'-oligoadenylate synthetase-like protein 1 , 2-5A synthase 1B , 2-5A synthetase 1B , Flavivirus resistance , inactive 2'-5'-oligoadenylate synthase 1B , 2'5' oligoadenylate synthetase-2 , 25 oligoadenylate synthetase-2