OAS1B Products
(2'-5' Oligoadenylate Synthetase 1B (OAS1B))
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This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008].
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OAS1B Antibodies
High quality antibodies with extensive validation data.
Recommended OAS1B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
West Nile Virus (WNV)
Application
IF, ELISA, WB
Validations
- (3)
- (1)
Cat. No.
ABIN2477148
Quantity
0.1 mg
Datasheet
Datasheet
Recommended OAS1B Proteins
Latest Publications for our OAS1B products
: "Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein." in: The Journal of general virology, Vol. 86, Issue Pt 2, pp. 405-12, (2005) (PubMed).: "West Nile virus: a growing concern?" in: The Journal of clinical investigation, Vol. 113, Issue 8, pp. 1102-7, (2004) (PubMed).
: "Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells." in: The Journal of biological chemistry, Vol. 279, Issue 52, pp. 54533-41, (2004) (PubMed).
Synonyms and alternative names related to OAS1B
2'-5' oligoadenylate synthetase 1B (Oas1b), 2-5 oligoadenylate synthetase 1B (Oas1b), (2-5')oligo(A) synthase 1B, 2-5A synthase 1B, Flv, L1, Mmu-L1, Oas1, Oias-2, Oias2, WnvProtein level used designations for OAS1B
- (2-5')oligo(A) synthase 1B
- (2-5')oligo(A) synthetase 1b
- 2',5'-oligoadenylate synthetase-like 1
- 2'-5'-oligoadenylate synthase 1B
- 2'-5'-oligoadenylate synthase-like protein 1
- 2'-5'-oligoadenylate synthetase-like protein 1
- 2-5A synthase 1B
- 2-5A synthetase 1B
- Flavivirus resistance
- inactive 2'-5'-oligoadenylate synthase 1B
- 2'5' oligoadenylate synthetase-2
- 25 oligoadenylate synthetase-2
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