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Report a novel positive function of mm9_circ_009056 during osteogenesis in regulating BMP7 through miR-22-3p. Furthermore, the expression of mm9_circ_009056 was up-regulated in CGRP-induced cells, whereas miR-22-3p was decreased.
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Hepatic PCT expression is upregulated in ALF. Hepatic macrophages but not hepatocytes are the cell source of hepatic PCT expression.
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alphaCGRP overexpression causes an increase in thermal reaction and downregulation of the cardiovascular system, presumably due in increased levels of alphaCGRP.
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Glucagon-like peptide (GLP)-1 modulates epithelial ion transport indirectly by activating calcitonin gene-related peptide (CGRP)-containing submucosal enteric neurons in the mouse colon. This GLP-1-CGRP response was area-specific and could potentially contribute to the diarrheal side effect of certain GLP-1 receptor therapeutics.
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This study demonstrated that the expression patterns of the calcitonin-related polypeptide alpha and tyrosine hydroxylase formed opposing gradients, with tyrosine hydroxylase being preferentially expressed in apical and calcitonin-related polypeptide alpha in basal type II afferent neurons, indicating heterogeneity among type II afferent neurons.
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CGRP-1 is essential for pain-associated plasticity in the central amygdala.
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These results suggest that neuronal TRPV1 signaling in periodontal tissue is crucial for the regulation of osteoclastogenesis via the neuropeptide CGRP.
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alphaCGRP played a synergic role in angiogenesis and osseointegration, partly as a consequence of its vasodilative activity.
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results indicate that CGRP regulates macrophage polarization and inhibits inflammation in murine macrophages.
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The results indicate a central role of neuroendocrine peptide aminoprocalcitonin (NPCT) in Alzheimer disease pathogenesis and suggest NPCT as a potential biomarker and therapeutic target.
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In addition to its actions in the cardiovascular system, endogenous CGRP is a key regulator of metabolism and energy homeostasis in vivo.
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findings establish CGRP neurons in the parabrachial nucleus as key mediators of cancer-induced appetite suppression and associated behavioral changes.
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These results identify an important, possibly dual role of CGRP in Amyotrophic lateral sclerosis pathogenesis.
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functional inactivation of CGRP neurons markedly increases meal size, with meal frequency being reduced in a compensatory manner, and renders mice insensitive to the anorexic effects of meal-related satiety peptides.
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Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
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The abundance of mRNA of CGRP and bone matrix markers (Col I, Col II, and OPN) was low at P5 in the tibia. These differences in CGRP and other mRNAs may induce a different manner of ossification between the mandible and tibia. Therefore, a time lag of ossification occurs between the mandible and tibia during foetal development.
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Suggest that cochlear function is enhanced by maturation of CGRP receptor complexes.
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the generation of Tregs may be promoted by naive CD4+ T cell: neuron interaction through the release of neuropeptide CGRP.
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The observations of this study imply that Adelta afferents expressing CGRP-IR transduce information from different sites within the skin.
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SHH may affect alveolar bone healing by interacting with CGRP-positive sensory neurons and thus regulate the socket's healing process after tooth extraction.
