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anti-Human FNDC5 Antibodies:
anti-Mouse (Murine) FNDC5 Antibodies:
anti-Rat (Rattus) FNDC5 Antibodies:
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Human Polyclonal FNDC5 Primary Antibody for IF (p), IHC (p) - ABIN1387505
Park, Kim, Choi, Heo, Park: New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. in Cellular signalling 2015
Human Polyclonal FNDC5 Primary Antibody for IHC, IHC (p) - ABIN4327646
Komolka, Albrecht, Schering, Brenmoehl, Hoeflich, Maak: Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle? in PLoS ONE 2014
Human Polyclonal FNDC5 Primary Antibody for WB - ABIN1169430
Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. in Cell metabolism 2013
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
Obese children had significantly higher irisin and lower oxytocin levels than the healthy controls.
We determined FNDC5 polymorphisms frequencies in the Israeli population and demonstrated that maternal and neonatal FNDC5 rs726344 polymorphism is significantly associated with increased risk for preterm birth. Women bearing FNDC5 rs726344 GG genotype had 2.18 fold higher chance to deliver on time compared to AG and AA genotypes.Neonatal carrying FNDC5 rs726344 GG genotype had 2.24 fold higher chance to be born on time.
Lower levels of irisin are independently associated with elevated skin AF values, indicating that circulating irisin levels could be associated with AGEs accumulation, which is one of the reasons causing vascular complications in diabetic patients.
Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity.
irisin was significantly higher in obese than in control children, and was inversely correlated with Acrp30 and high molecular weight (HMW) oligomers; inverse correlation between Irisin and Acrp30 and, more significantly, between Irisin and HMW oligomers suggests that the two cytokines are closely connected
Irisin is an oxidative stress marker and a metabolic protective hormone.
Mild cold exposure increased vasoconstriction with a drop in in-the-ear temperature and these were related. Greater irisin was related to a greater fasting fat oxidation in the absence of shivering
Activation of the nuclear receptor constitutive androstane receptor (show NR1I3 Antibodies) (CAR) induced FNDC5 mRNA expression in the liver.
HCC (show FAM126A Antibodies)-liver tissue over-expressed FNDC5/Irisin in association with gene expression of mediators involved in lipogenesis, inflammation and cancer, suggesting a possible protective role of the hormone from the liver damage.
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (show INS Antibodies) biosynthesis and glucose-stimulated insulin (show INS Antibodies) secretion, and beta-cell apoptosis are reported.
FNDC5 is overexpressed in skeletal muscle and adipose tissue of insulin (show INS Antibodies) resistant high fat-fed mice.
This study for the first time showed that adipocytes are directly affected by irisin (Fndc5) and provides an evidence on anti-inflammatory action of irisin on fat cells.
Mstn (show MSTN Antibodies) regulates Fndc5/Irisin expression and secretion through a novel miR (show MLXIP Antibodies)-34a-dependent post-transcriptional mechanism; loss of Mstn (show MSTN Antibodies) in mice leads to the increased Fndc5/Irisin expression, which contributes to the browning of white adipocytes
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD (show TSC2 Antibodies) without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (show HMOX1 Antibodies)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Antibodies) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 Antibodies)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
these results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin]
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein