Browse our anti-IGF2 (IGF2) Antibodies

Human Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. This study revealed that miR-483-3p derived from IGF2 was associated with Hirschsprung's disease by targeting FHL1 and may provide a new pathway to understand the aetiology of Hirschsprung's disease.

2. study proposes that regulation of IGF2 expression in normal cervical epithelium appeared to be multifaceted and deregulation during the development of Uterine cervical carcinoma resulted in the differential expression.

3. To escape EGFR-TKI treatment, CCA tumor cells develop an adaptive mechanism by undergoing an IR/IGF1R-dependent phenotypic switch, involving a contribution of stromal cells.

4. IGF2 is identified for the first time as a direct target of miR-210 in HRECs, adding new mechanistic insights into the expression regulation of pro-angiogenic IGF2 in human retinal endothelial cells.

5. The role of IGF2 in angiogenesis was further supported by our in vivo experiments in the CAM assay and zebrafish, which show that sprouting in the absence of IGF2 mRNA is chaotic and irregular.

6. Children with biobehavioral reactivity to challenge and were inhibited were found to have decreased DNA methylation of the DLX5 and IGF2 genes at both time points, as compared to non-reactive, disinhibited children.

7. Igf2, a maternal imprinted gene, and c-jun, a proto-oncogene, are regulated by p53 in these cells. DNA damage leads to an increase in p53 abundance in human amniotic fluid cells and to transcriptional activation of its target genes. Interestingly, cell differentiation toward the neural lineage leads to p53 induction as differentiation progresses.

8. Study in infertile men reports for the first time that methylation levels of IGF2 (cg17037101) and KCNQ1 (cg24932449) are associated with sperm DNA damage.

9. we aimed to evaluate serum levels of IGF-1, IGF-2 and IGF-binding protein 3 (IGF-BP3) before and after standard treatment in patients with advanced non-small cell lung cancer (NSCLC) and their prognostic and predictive correlations.

10. Results found the expression levels of IGF2 and CD133 positively correlated with each other in primary esophageal squamous cell carcinoma (ESSC), and their concurrent increased expression was significantly associated with poor patient survival. Knockdown of IGF2 or treatment with PI3K/AKT inhibitors markedly inhibited the abilities of CD133-positive ESCC cells to self-renew, resist chemotherapeutic drugs, and form tumors.

11. Study provide evidence that the enhancer at IGF2 regulates the rate-limiting enzyme in dopamine synthesis tyrosine hydroxylase (TH). This work suggests a mechanism for epigenetic regulation of dopamine levels in the brain. Epigenetic misregulation of an enhancer at IGF2 may underlie the dopaminergic abnormalities that drives psychotic symptoms.

12. An association was found between IGF2 methylation in maternal blood and birth weight.

13. This study was planned to test whether follicular fluid (FF) levels of patatin-like phospholipase domain containing 3-gene (PNPLA3:adiponutrin), preptin, kisspeptin, and amylin change in polycystic ovarian syndrome.

14. Long noncoding RNA insulin growth factor 2 antisense is acting as an epigenetic tumor suppressor in human prostate cancer, likely through inverse regulation on IGF2

15. IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling

16. These findings not only confirm the role of the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.

17. Results showed significant correlation between ROS levels and H19-Igf2 gene methylation as well as semen parameters. These findings are critical to identify idiopathic male infertility and its management through assisted reproduction technology

18. in LOI cells, we find a reversal of the relative activities of two canonical signaling pathways triggered by IGF2, causing further rebalancing between pro- and anti-apoptotic signaling.

19. findings uncovered the mechanistic basis for differential HIF-1alpha-mediated regulation of BNIP3 and IGF2, indicating that copper regulates target gene selectivity of HIF-1alpha at least in part by affecting HIF-1alpha binding to its cognate HRE in the promoters of these two genes

Zebrafish Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. ith respect to the different IGFs produced locally, a decrease in igf1a expression and a significant increase in both igf2a and igf2b expression was observed, suggesting that igf1a is not directly involved in fin regeneration. Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process.

2. Igf2 regulates early neural and cardiovascular development in zebrafish embryos.

3. The IGF2 expression has also been reported at earlier stages in fish.

4. zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.

Mouse (Murine) Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. Paternal developmental TCDD exposure is associated with transgenerational placental dysfunction, suggesting epigenetic modifications within the sperm have occurred. To assess if Pgr and Igf2 DNA methylation changes were present in sperm and persist in future generations, we assessed methylation and expression of these genes in F1/F3 sperm and F3-derived placentae.

2. Together, our data indicate that Igf2 deficiency leads to a newborn phenotype strongly reminiscent of nutritional deficiency, including growth retardation, increased brain/body weight ratio, hepatic steatosis, and characteristic changes in hepatic gene expression.

3. HIF-1 alpha: a key survival factor for serum-deprived prostate cancer cells.

4. Study discovered that light-induced enhancement of recognition memory occurs in tandem with pronounced changes in hippocampal genetic programs as up-regulation of Igf2, and proposes that light-induced changes in hippocampal clock function leads to the de-repression of IGF2, which primes the hippocampus to enhance the acquisition and consolidation of long-term recognition memory.

5. Myogenesis-associated long noncoding rna promotes myogenesis by functioning as a competing endogenous RNA for microRNA-125b to control protein abundance of IGF2.

6. DIS3L2 loss of function results in transcriptional activation of the Igf2/H19 locus in nephron progenitor cells, most likely by leading to the activation of shared cis-regulatory elements that control these genes.

7. the effect of ZBED6 on growth of muscle and internal organs is mediated through the binding site in the Igf2 gene

8. Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.

9. HMGA1P7 mRNA sustains the H19 and Igf2 overexpression by acting as miRNA decoy.

10. IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line

11. IGF2 is silenced in mouse embryos by the zinc finger protein ZFP568

12. Loss of imprinting at the Igf2/H19 locus disrupts in vitro differentiation of primary myoblasts.

13. Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.

14. These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 but not p38 MAPK or Erk1/2 MAPK pathways.

15. produced by pericentral hepatocytes to promote hepatocyte proliferation and repair tissue damage in the setting of chronic liver injury

16. Here the authors show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.

17. Loss of Igf2 Gene Imprinting is associated with Prostate Cancer.

18. IGF2 controls bone growth by regulating glucose metabolism in chondrocytes.

19. These results demonstrate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage testing of MEDI-573, alone and in combinations, in IGF2-overexpressing CRC patients.

20. results demonstrate that the H19-Igf2 axis is negatively regulated by CTCF-PHB1 cooperation and that H19 is involved in modulating the growth-suppressive effect of PHB1 in the liver.

Pig (Porcine) Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. Our study confirmed the important effect of a mutation in the ZBED6 binding site motif on IGF2 expression and myogenesis, thus providing the basis for breeding a new line of Liang Guang Small Spotted pigs with improved lean meat percentage, a trait of great commercial value to pig producers.

2. These results indicated that editing IGF2 intron 3-3072 site using CRISPR-Cas9 technology improved meat production in Bama pigs.

3. trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.

4. A single nucleotide polymorphism in a regulatory region of intron 3 within the porcine IGF2 gene is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles compared with pigs with paternal G alleles.

5. These findings indicated that the mRNA of H19 and IGF2 genes is susceptible to in vitro environments during the process of ES cell derivation from blastocysts but DNA methylation status at this region was well maintained.

6. study did not find any significant associations for polymorphisms in insulin-like grwoth factor 2, GTP Binding Protein alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs

7. The results suggested that IFG-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.

8. Genetic variation in the promoter region of the IGF2 gene is associated with intramuscular fat content in porcine skeletal muscle.

9. The IGF2 G allele has strong adipogenic effects at the subcutaneous adipose tissue level and enhances the intermuscular fat content in ham.

10. IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

11. The imprinting status in adult liver, muscle and kidney tissues were also not reflected in the methylation patterns of IGF2 DMRs 1 and 2.

12. The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.

13. The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.

14. Promoter-specific expression differences of IGF2 isoforms and IGF2AS between biparental and parthenogenetic swine fetal tissues were documented. IGF2 and IGF2AS are paternally expressed.

15. In both skeletal muscle and heart muscle growth, the insulin-like growth factor-2:myostatin interaction seems to play an important role.

16. Effect of genotype on proteolytic enzyme in skeletal muscles during growth.

17. Mutation controls the paternally expressed QTL for backfat thickness in a cross between Meishan and European Whites.

18. A significant effect of linkage disequilibrium between IGF2-in3-G3072A and IGF2-in7-G162C on backfat thickness and lean meat content was found.

19. Results showed that in IGF2 gene, the predominant allele was C, and the predominant genotype was CC. and that Wuzhishan pig breed was at Hardy-Weinberg equilibrium with respect to this SNP.

20. The majority of IGF2 transcripts are expressed from promoters 2-4 and are imprinted.

Cow (Bovine) Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.

2. Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program

3. The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.

4. Polymorphisms in the IGF2 gene are associated with cattle growth traits.

5. The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

6. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.

7. The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 and IGF-2) and in the jejunum (IGF-1) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).

8. Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.

9. Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

10. findings support work which suggests that the insulin-like growth factor 2 locus is an important biological regulator of milk production in dairy cattle

11. effects of insulin, IGF-I and IGF-II on apoptosis and cell proliferation in bovine blastocysts in vitro

12. IGF2 is subjected to extensive transcriptional regulation through multiple promoters, alternative splicing and polyadenylation, as well as genetic imprinting.IGF2 regulation is age-, tissue-, promoter-, and allele-specific

13. Identification of a previously unknown differentially methylated region in exon 10 of the bovine IGF2 gene.

14. Indel polymorphism associated with breeding value in bulls.

15. The role of insulin-like growth factor 2 (IGF2) and the regulation of the IGF2 receptor (IGF2R) during follicular development were studied.

16. Embryonic tissues from NT-derived embryos had higher expression of IGF-II mRNA than in vitro production embryonic tissues.

17. The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.

18. study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos

19. Dats detected that SNPs of IGF2 gene has close relationship with carcass and meat quality traits in Qinchuan cattle

20. Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle.

Rabbit Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin and IGF.

Horse (Equine) Insulin-Like Growth Factor 2 (IGF2) interaction partners

1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

2. Methylation of three selected CpG islands of promoter of equine IGF2 gene was comparable between young and old horses, suggesting that aging could not be considered as a factor modulating methylation status of selected CpG islands within equine IGF2 gene.