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Human Monoclonal NPPB Primary Antibody for IHC, ELISA - ABIN965690
Pfister, Erdmann, Schneider: [Natriuretic peptides BNP and NT-pro-BNP--the "new troponins" for estimation of heart failure?]. in Deutsche medizinische Wochenschrift (1946) 2003
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Human Monoclonal NPPB Primary Antibody for IA, ELISA - ABIN253336
Bu, Zhou, Tang, Jing, Zhang: Expression and purification of a novel therapeutic single-chain variable fragment antibody against BNP from inclusion bodies of Escherichia coli. in Protein expression and purification 2013
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Mouse (Murine) Polyclonal NPPB Primary Antibody for IF (p), IHC (p) - ABIN678623
Rigazio, Hernández, Corral: Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection. in Microbial pathogenesis 2014
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Human Monoclonal NPPB Primary Antibody for IHC, ELISA - ABIN1724677
Dawson, Struthers: Screening for treatable left ventricular abnormalities in diabetic patients. in Expert opinion on biological therapy 2003
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Human Monoclonal NPPB Primary Antibody for IP, ELISA - ABIN518426
Chiu, Chen, Su, Lee, Hsieh, Ho: The arrhythmogenic effect of self-assembling nanopeptide hydrogel scaffolds on neonatal mouse cardiomyocytes. in Nanomedicine : nanotechnology, biology, and medicine 2014
Human Monoclonal NPPB Primary Antibody for ELISA (Detection), ELISA - ABIN263370
Crimmins, Kao: A glycosylated form of the human cardiac hormone pro B-type natriuretic peptide is an intrinsically unstructured monomeric protein. in Archives of biochemistry and biophysics 2008
CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals
ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations.
Up-regulation of BNP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a in failing myocardium are observed in a porcine model of tachycardia.
serum levels predict mortality in chest pain patients in Argentina
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.
identification and characterization of a novel alternatively spliced variant of porcine and human NPPB resulting from exon 2 skipping
Arial natriuretic factor (ANF) and N-terminal proANF may be better suited than brain natriuretic peptide as markers of cardiac preload during the development and treatment of acute heart failure.
Regional differences in BNP and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.
Higher preoperative NT-proBNP level leads to the increased risk of peri-operative major cardiac events in patients undergoing non-cardiac surgery.
NT-proBNP levels were an independent biomarker associated with an increased all-cause mortality in older Chinese patients with atrial fibrillation.
Increased brain natriuretic peptide is associated with significant excess of incident cardiovascular events and mortality in HIV-infected patients.
combination of NT-proBNP with GDF-15 mRNAlevel in the circulating mononuclear cells can more accurately predict the risk of long-term cardiovascular disease events
Patients with incomplete Kawasaki disease (IKD) had higher NT-proBNP levels than patients with other febrile diseases, and the proportion of cases of elevated age-adjusted NT-proBNP level was also higher in the IKD group.
NT-proBNP is a useful prognostic indicator of long-term mortality in acute heart failure even in the obese patient.
Biomarkers NT-proBNP and apoCIII substantially increment the prediction of cardiovascular disease in type 2 diabetes.
In preterm patients, elevated NT-proBNP levels are related to worse diastolic myocardial function. In the first 24 h, this correlation is much stronger in the absence of patent ductus arteriosus (PDA).
Asymptomatic elevation of BNP is strongly predictive for cardiovascular events and heart failure, which might help to integrate cardio-renal risk stratification in predialysis chronic kidney disease patients.
BNP levels were associated with sarcopenia in type 2 diabetic patients without heart failure.
Increased proBNP levels could be associated with a significant increased risk of necrotizing enterocolitis in very immature newborns
The NT-proBNP levels were higher in fetuses of patients with preeclampsia than in gestational hypertension and controls.
Amniotic fluid NT-proBNP concentrations increase in stepwise fashion with the severity of heart failure in fetuses with CHD or arrhythmia; it was the optimal NP for assessing the fetal HF.
The addition of NT-proBNP to variables of established risk scores improves prediction of stroke, with a medium effect size
BNP levels were analysed in 1. cognitively healthy, control subjects; 2. subjects with mild cognitive impairment, and 3. subjects with Alzheimer's disease. The results show that the levels of BNP were significantly different between the three types of diagnoses (p < 0.05), whereby subjects with mild cognitive impairment had the lowest mean BNP value, and healthy subjects had the highest BNP value.
In adult congenital heart disease patients NT-proBNP increased before the occurrence of events, especially in patients who died or developed heart failure.
BNP can independently identify patients with subtle impairment of cardiac function that might benefit from more intensive management.
In patients with hypertension, BNP is superior to ventricular dysfunction on echocardiography in the prediction of risk of major adverse cardiovascular events.
In this review, we summarise the current knowledge of SERCA2a gene therapy for heart failure, analyse potential interaction between BNP levels and therapeutic effects of SERCA2a gene transfer and provide directions for future research to solve the identified problems.
High NT-proBNP levels contribute to increased risk of malnutrition in older patients with heart failure.
Atopic dermatitis linked cytokine interleukin-31 induced itch is mediated via a NPPB pathway.
These results suggested that the papillary tip express a substance that can stimulate BNP production and secretion from cardiomyocytes.
This study provides the first evidence of the ability of IL-18 to induce B-type natriuretic peptide synthesis in vitro and outlines the relationship between the two molecules in acute HF patients with an ongoing inflammatory status.
The present study provides a novel insight into the potential underlying mechanisms of telmisartan-induced inhibition of cardiomyocyte hypertrophy, which involves inhibition of NFAT activation, nuclear translocation and the ANP/BNP cascade.
the developmental regulation and stress response of the Nppa-Nppb cluster involve the concerted action of multiple enhancers and epigenetic changes distributed across a structurally rigid regulatory domain.
Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
we have validated a novel gene, Myh14, as a negative regulator of ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls.
P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide and facilitatory calcitonin gene-related peptide that both operate via complex intracellular signaling.
mouse trigeminal neurons endogenous BNP acts on NPR-A receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A/PKG pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments
The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.
Data (including data from studies in knockout mice) suggest expression of ANP/BNP/GC-A (atrial natriuretic peptide, brain natriuretic peptide, and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.
Goalpha plays a role in ANF sorting during intracellular vectorial transport and with the presence of a mechanism that preserves the molar relationship between cellular ANF and BNP.
The RNA-Seq demonstrates that NPPB which well activates natriuretic peptide receptor 1 (NPR1), is well expressed in mouse dorsal root ganglian.
a slow modulatory action by BNP on TRPV1 and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
These data provide detailed novel insight into the complex effects of natriuretic peptides and their receptors on electrical conduction in the heart.
Natriuretic peptides buffer renin-dependent hypertension.
BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway.
Data indicate that the identified stress-responsive enhancer of Nppa and Nppb, the most common markers of heart failure, is a 650-bp fragment within 50 kb of the Nppa and Nppb loci.
these results define the primary pruriceptive neurons, characterize Nppb as an itch-selective neuropeptide, and reveal the next two stages of this dedicated neuronal pathway.
Elevated BNP levels, by inducing sympathetic overdrive and altering Ca(2+) handling, promote adverse cardiac remodelling and ventricular arrhythmias
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
gamma-brain natriuretic peptide
, natriuretic peptides B
, brain type natriuretic peptide
, natriuretic peptide precursor B
, natriuretic protein
, brain natriuretic peptide
, Brain natriuretic factor
, natriuretic peptide precursor type B
, Gamma-brain natriuretic peptide