NPPB antibody (AA 1-134)

Catalog No. ABIN3023136

This Rabbit Polyclonal antibody specifically detects NPPB in WB and IF. It exhibits reactivity toward Human.

Quick Overview for NPPB antibody (AA 1-134) (ABIN3023136)

Target: NPPB (Natriuretic Peptides B (NPPB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPPB antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-NPPB Antibody

Binding Specificity: AA 1-134

Sequence: MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PRSPKMVQGS GCFGRKMDRI SSSSGLGCKV LRRH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human BNP (NP_002512.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NPPB

Target: NPPB (Natriuretic Peptides B (NPPB))

Alternative Name: NPPB

Background: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.,NPPB,BNP,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Cardiovascular,Angiogenesis,Blood,Blood Pressure regulation,Heart,Hypertrophy,NPPB

Molecular Weight: 14 kDa

Gene ID: 4879

UniProt: P16860

Pathways: Hormone Activity