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Human Polyclonal HNF1B Primary Antibody for ICC, IF - ABIN4358082
Donthamsetty, Bhave, Mars, Bowen, Orr, Haynes, Wu, Michalopoulos: Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. in PLoS ONE 2013
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Cow (Bovine) Polyclonal HNF1B Primary Antibody for WB - ABIN2777700
Hakonarson, Qu, Bradfield, Marchand, Kim, Glessner, Grabs, Casalunovo, Taback, Frackelton, Eckert, Annaiah, Lawson, Otieno, Santa, Shaner, Smith, Onyiah, Skraban, Chiavacci, Robinson, Stanley, Kirsch et al.: A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. ... in Diabetes 2008
Human Monoclonal HNF1B Primary Antibody for ELISA, WB - ABIN520763
Debiais-Delpech, Godet, Pedretti, Bernard, Irani, Cathelineau, Cussenot, Fromont: Expression patterns of candidate susceptibility genes HNF1? and CtBP2 in prostate cancer: association with tumor progression. in Urologic oncology 2014
Human Polyclonal HNF1B Primary Antibody for ELISA, ICC - ABIN334505
Terasawa, Toyota, Sagae, Ogi, Suzuki, Sonoda, Akino, Maruyama, Nishikawa, Imai, Shinomura, Saito, Tokino: Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. in British journal of cancer 2006
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Dog (Canine) Polyclonal HNF1B Primary Antibody for ELISA, WB - ABIN547833
Arenas, Hervias, Uriz, Joplin, Prieto, Medina: Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. in The Journal of clinical investigation 2008
In 263 Japanese partients with suspected maturity-onset diabetes of the young, mutations were identified in 103 (39.2%) patients: 57 mutations in GCK; 29, HNF1A; 7, HNF4A; and 10, HNF1B.
Mutations of HNF1B gene is associated with Maturity-onset diabetes of the young type 5.
The evidence and helps to reveal that common variants of HNF1B are associated with risk of prostate and endometrial cancer.
Maturity Onset Diabetes of the Young due to Glucokinase, HNF1-A, HNF1-B, and HNF4-A Mutations in a Cohort of Turkish Children Diagnosed as Type 1 Diabetes Mellitus
Clinical phenotypes of HNF1B-related disease are heterogeneous, renal malformations clearly appear to be the most common manifestation, multiple renal cysts are characteristic, and patients can progress to impaired kidney function during childhood; HNF1B mutation is a differential diagnosis of fetal hyperechogenic kidneys or multiple renal cysts
In a cohort of patients with developmental renal disease, results identified a shared DNA methylation signature in both mutation and deletion patient groups indicating that haploinsufficiency of HNF1B impacts on the methylome of a number of genes, giving further insight to the role of HNF1B.
This study confirmed the presence of a not previously described heterozygous genetic variant of the HNF1B gene in Chilean children with congenital anomalies of the kidney and urinary tract.
Isolate living subpopulations of duct cells enriched for high or low expression of HNF1beta and SOX9.
findings suggest a protective character for the GG genotype in the development of T2DM, which appears applicable to elderly individuals as well.
HNF-1beta enhances the stemness of hepatocellular carcinoma cells through activation of the Notch pathway.
HNF1B p.Arg527Gln nonsense mutation mutation is associated with atypical early onset diabetes and diabetic nephropathy.
Loss of HNF1B in renal epithelial cells Results in Kidney Disease with Cysts.
HNF1B gene rs4430796 G allele may be associated with increased risk of Gestational Diabetes. Additionally, women in HNF1B rs4430796 AG genotype were observed to have a higher BMI increase during pregnancy.
HNF1beta is a transcriptional activator of Kcnj16. Hence, patients with HNF1beta mutations may have reduced Kir5.1 activity in the kidney, resulting in hypokalemia and hypomagnesemia.
HNF-1B plays a critical role in lipid and glucose homeostasis in second trimester of pregnancy
Data suggest that a missense mutation in HNF1B (c.1007A>G; p.H336R) can result in maturity-onset diabetes of the young type 5; study involved 30-year-old woman and her 58-year-old mother in a Chinese family. [CASE REPORT]
In patients with HNF1B syndrome, diabetes complications, cardiovascular risk factors, chronic kidney disease stages 3-4, and end-stage renal disease are highly prevalent.
HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer
HNF1B mutation represents a differential diagnosis of polyhydramnios associated with hyperechogenic (and sometimes enlarged) kidneys
The functional, biochemical, and structural characterisation of the nuclear localisation signal present on HNF1beta and its interaction with the nuclear import protein Importin-alpha.
Hnf1beta and Fzd4/Fzd4s appear to be involved in pre-patterning events of the embryonic endoderm that allow pancreas formation in Xenopus.
Overexpression of two mutant HNF1B derivatives resulted in distinct phenotypes reflected by either a reduction or an enlargement of pronephros size.
nephrogenic transcription factors (osr1, osr2, hnf1b, lhx1, pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A, retinoic acid
CHOP (GADD153) is an inhibitor of Wnt/TCF signals
HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16.Thus, HNF1beta is a transcriptional activator of Kcnj16.
Results provide evidence that downregulation of HNF1b and activation of reactive oxygen species/NF-kappaB-mediated in fl ammation play an important role in PCB-153-induced glucose/lipid metabolic disorder.
Hnf1b deletion leads to massively mispatterned ureteric tree network, defective collecting duct differentiation and disrupted tissue architecture, which leads to cystogenesis. This study uncovers a fundamental and recurring role of HNF1B in epithelial organization during early ureteric bud branching and in further patterning and differentiation of the collecting duct system in mouse.
This review discusses the role of HNF1B in human and murine pancreas and liver development, summarizes the disease phenotypes and identifies areas for future investigations in HNF1B-associated diabetes and liver disease. [Review Article]
role in osmoregulation in renal collecting ducts
These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells.
HNF-1beta Regulates MicroRNA-200 Expression through a Long Noncoding RNA
TNFalpha regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin.
Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha.
Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta.
HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.
Hepatocyte nuclear factor 1beta controls nephron tubular development.
identification of Hnf1b as a target of miR-802-dependent silencing; show that short hairpin RNA (shRNA)-mediated reduction of Hnf1b in liver causes glucose intolerance, impairs insulin signalling and promotes hepatic gluconeogenesis
Hnf1b and Pax2 operate to control kidney morphogenesis and ureter differentiation.
Overexpression of HNF1beta resulted in accelerated cell proliferation with the protein level up-regulation of plasminogen and plasmin, a converted active form of plasminogen, which play a pivotal role in liver regeneration inducing hepatocyte proliferation.
Data indicate that HNF1alpha is a more potent activator of AFM promoter than is HNF1beta.
Study identifies new direct target genes of the Hnf1b transcription factors and shows that they play crucial roles in both defining cell fate and controlling terminal functions in the gut epithelium.
transcriptional hierarchy between HNF-1beta and PKD (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested, and collectrin is one of such HNF-1beta regulated genes
analysis of isoform-specific expression of the human, mouse and rat HNF1A, HNF1B and HNF4A genes
Data show that hnf1ba generates a permissive domain for Wnt signaling activity in the foregut endoderm
essential for normal segmentation of nephrons during kidney organogenesis
Knockdown of pk1a led to decreased expression of vhnf1, a homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation; forced expression of vhnf1 mRNA led to rescue of the pk1a morphant phenotype
Data show that vhnf1 functions in two ways to subdivide the zebrafish caudal hindbrain domain (r4-r7) into individual rhombomeres.
Zebrafish tcf2 gene, composed of 9 exons, was mapped to linkage group LG15.
vhnf1 acts largely independently of val to repress the rhombomere 4 'hox code' posterior to the rhombomere 4-5 boundary
Vhnf1 expression within the posterior neural tube (up to r5) promotes posterior and dorsal fates in the otic vesicle, at the expense of anterior and ventral fates.
investigated the signaling pathways that regulate vhnf1 expression during pancreas development
Data show that zebrafish mutants for Tcf2 fail to specify a single lumen in their gut tube and instead develop multiple lumens, and show that Tcf2 controls single lumen formation by regulating claudin15 and Na+/K+-ATPase expression.
vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification.
It was concluded that hnf1b(hi2169) is hypomorphic to hnf1b(hi1843) and that, while hnf1b is required for r5/r6 gene expression in the hindbrain, r5/r6 gene expression can be experimentally induced independently of hnf1b anterior to the hindbrain.
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
, HNF1 homeobox B
, HNF1 beta A
, hepatocyte nuclear factor 1-beta
, homeoprotein LFB3
, transcription factor 2, hepatic
, FPC-binding protein
, variant hepatic nuclear factor 1
, hepatocyte nuclear factor-1 beta
, transcription factor 2
, Transcription factor 2 hepatic
, Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor
, Transcription factor 2, hepatic
, Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
, hepatocyte nuclear factor 1 beta
, HNF1 homeobox b
, hepatocyte nuclear factor 1-beta-2
, hepatocyte nuclear factor 1-beta-A