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Human Polyclonal HNF1B Primary Antibody for ICC, IF - ABIN4358082
Donthamsetty, Bhave, Mars, Bowen, Orr, Haynes, Wu, Michalopoulos: Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. in PLoS ONE 2013
Show all 4 Pubmed References
Human Monoclonal HNF1B Primary Antibody for ELISA, WB - ABIN520763
Debiais-Delpech, Godet, Pedretti, Bernard, Irani, Cathelineau, Cussenot, Fromont: Expression patterns of candidate susceptibility genes HNF1? and CtBP2 in prostate cancer: association with tumor progression. in Urologic oncology 2014
Human Polyclonal HNF1B Primary Antibody for ELISA, WB - ABIN334505
Terasawa, Toyota, Sagae, Ogi, Suzuki, Sonoda, Akino, Maruyama, Nishikawa, Imai, Shinomura, Saito, Tokino: Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. in British journal of cancer 2006
Show all 2 Pubmed References
Cow (Bovine) Polyclonal HNF1B Primary Antibody for WB - ABIN2777700
Hakonarson, Qu, Bradfield, Marchand, Kim, Glessner, Grabs, Casalunovo, Taback, Frackelton, Eckert, Annaiah, Lawson, Otieno, Santa, Shaner, Smith, Onyiah, Skraban, Chiavacci, Robinson, Stanley, Kirsch et al.: A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. ... in Diabetes 2008
Loss of HNF1B in renal epithelial cells Results in Kidney Disease with Cysts.
HNF1B gene rs4430796 G allele may be associated with increased risk of Gestational Diabetes. Additionally, women in HNF1B rs4430796 AG genotype were observed to have a higher BMI increase during pregnancy.
HNF1beta is a transcriptional activator of Kcnj16. Hence, patien (show KCNJ16 Antibodies)ts with HNF1beta mutations may have reduced Kir5.1 activ (show KCNJ16 Antibodies)ity in the kidney, resulting in hypokalemia and hypomagnesemia.
HNF-1B plays a critical role in lipid and glucose homeostasis in second trimester of pregnancy
Data suggest that a missense mutation in HNF1B (c.1007A>G; p.H336R) can result in maturity-onset diabetes of the young type 5; study involved 30-year-old woman and her 58-year-old mother in a Chinese family. [CASE REPORT]
In patients with HNF1B syndrome, diabetes complications, cardiovascular risk factors, chronic kidney disease stages 3-4, and end-stage renal disease are highly prevalent.
HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer
HNF1B mutation represents a differential diagnosis of polyhydramnios associated with hyperechogenic (and sometimes enlarged) kidneys
The functional, biochemical, and structural characterisation of the nuclear localisation signal present on HNF1beta and its interaction with the nuclear import protein Importin (show KPNA2 Antibodies)-alpha.
HNF1beta was a direct target of miR (show MLXIP Antibodies)-217, and played oncogenic role in glioma cells.
Hnf1beta and Fzd4/Fzd4s appear to be involved in pre-patterning events of the embryonic endoderm that allow pancreas formation in Xenopus.
Overexpression of two mutant HNF1B derivatives resulted in distinct phenotypes reflected by either a reduction or an enlargement of pronephros size.
nephrogenic transcription factors (osr1 (show OSR1 Antibodies), osr2, hnf1b, lhx1 (show LHX1 Antibodies), pax8 (show PAX8 Antibodies))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Antibodies), retinoic acid
CHOP (GADD153 (show DDIT3 Antibodies)) is an inhibitor of Wnt (show WNT2 Antibodies)/TCF (show HNF4A Antibodies) signals
HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16 (show KCNJ16 Antibodies).Thus, HNF1beta is a transcriptional activator of Kcnj16 (show KCNJ16 Antibodies).
Results provide evidence that downregulation of HNF1b and activation of reactive oxygen species/NF-kappaB (show NFKB1 Antibodies)-mediated in fl ammation play an important role in PCB (show PC Antibodies)-153-induced glucose/lipid metabolic disorder.
Hnf1b deletion leads to massively mispatterned ureteric tree network, defective collecting duct differentiation and disrupted tissue architecture, which leads to cystogenesis. This study uncovers a fundamental and recurring role of HNF1B in epithelial organization during early ureteric bud branching and in further patterning and differentiation of the collecting duct system in mouse.
This review discusses the role of HNF1B in human and murine pancreas and liver development, summarizes the disease phenotypes and identifies areas for future investigations in HNF1B-associated diabetes and liver disease. [Review Article]
These results demonstrated the crucial role of Hnf1b and Foxa3 (show FOXA3 Antibodies) in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs (show HLCS Antibodies) from ES cells.
HNF-1beta Regulates MicroRNA-200 Expression through a Long Noncoding RNA
TNFalpha (show TNF Antibodies) regulates uromodulin (show UMOD Antibodies) expression in a homeostatic setting, but the impact of TNFalpha (show TNF Antibodies) on uromodulin (show UMOD Antibodies) during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin (show UMOD Antibodies).
Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha (show HIF1A Antibodies).
Zyxin (show ZYX Antibodies) regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta.
Data show that hnf1ba generates a permissive domain for Wnt (show WNT2 Antibodies) signaling activity in the foregut endoderm
Knockdown of pk1a led to decreased expression of vhnf1, a homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation; forced expression of vhnf1 mRNA led to rescue of the pk1a morphant phenotype
Data show that vhnf1 functions in two ways to subdivide the zebrafish caudal (show CAD Antibodies) hindbrain domain (r4-r7) into individual rhombomeres.
Zebrafish tcf2 gene, composed of 9 exons, was mapped to linkage group LG15.
vhnf1 acts largely independently of val to repress the rhombomere 4 'hox (show MSH2 Antibodies) code' posterior to the rhombomere 4-5 boundary
Vhnf1 expression within the posterior neural tube (up to r5) promotes posterior and dorsal fates in the otic vesicle, at the expense of anterior and ventral fates.
investigated the signaling pathways that regulate vhnf1 expression during pancreas development
Data show that zebrafish mutants for Tcf2 fail to specify a single lumen in their gut (show GUSB Antibodies) tube and instead develop multiple lumens, and show that Tcf2 controls single lumen formation by regulating claudin15 and Na+/K+-ATPase (show ATP1A1 Antibodies) expression.
vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification.
It was concluded that hnf1b(hi2169) is hypomorphic to hnf1b(hi1843) and that, while hnf1b is required for r5/r6 gene expression in the hindbrain, r5/r6 gene expression can be experimentally induced independently of hnf1b anterior to the hindbrain.
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
, HNF1 homeobox B
, HNF1 beta A
, hepatocyte nuclear factor 1-beta
, homeoprotein LFB3
, transcription factor 2, hepatic
, FPC-binding protein
, variant hepatic nuclear factor 1
, hepatocyte nuclear factor-1 beta
, transcription factor 2
, Transcription factor 2 hepatic
, Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor
, Transcription factor 2, hepatic
, Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
, hepatocyte nuclear factor 1 beta
, HNF1 homeobox b
, hepatocyte nuclear factor 1-beta-2
, hepatocyte nuclear factor 1-beta-A