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In recent years, the roles of zinc dynamics and MT3 function in neurodegeneration are slowly emerging. This short review focuses on the recent developments regarding the chemistry and biology of MT3. [review]
C-terminal domain of MT3 confers dome formation in MCF-7 cells and the presence of this domain induces expression of the GAGE family of genes. The differential effects of MT3 and metallothionein 1E (show MT1E Proteins) on the expression of GAGE genes suggests unique roles of these genes in the development and progression of breast cancer.
The expression of MT-3 mRNA in breast cancer cell lines was significantly lower than in the normal human breast epithelial cell line. The results suggest that MT-3 may play a role in the malignant transformation of breast epithelial cells and in tumor progression.
The epidermis of human skin and resulting malignancies express high level of MT-3.
The present study was undertaken to explore further the interrelationship between p53 (show TP53 Proteins) and metallothioneins.
The study implicates the unique C-terminal sequence of MT-3 in the conversion of HK-2 (show HK2 Proteins) cells to display an enhanced epithelial phenotype.
MT3 may regulate breast cancer cell invasiveness by modulating the expression of MMP3 (show MMP3 Proteins).
The presence of MT-3 in the zona glomerulosa of pathological adrenal cortex may imply a role in the pathophysiology of aldosterone-producing tissues.
MT-capital I, Ukrainiancapital I, Ukrainiancapital I, Ukrainian increases the amount of active ADAM10 (show ADAM10 Proteins) in association with furin (show FURIN Proteins), PC7 (show PCSK7 Proteins) and PKCalpha (show PKCa Proteins).
Upregulation of MT-3 gene expression can inhibit esophageal cancer cell proliferation and induce apoptosis.
the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization.
Circadian time and lighting could be involved in the regulation of the expression of melatonin receptors MTNR3 and Rorc (show RORC Proteins).
Mt3 may act through PDE3a (show PDE3A Proteins) to play a key role in Zinc dyshomeostasis and cell death in streptozotocin-treated islets.
Zn released from MT3 may contribute to VEGF (show VEGFA Proteins) induction.
The entire MT3 peptide shows a high capacity to bind Cu(+) , provided that this occurs in a nonoxidative milieux. This reflects a peculiar property of this MT isoform, which senses different Cu contents in the environment in which it is synthesized.
MT-III can help protect against light-induced retinal damage compared to MT-I (show MT1 Proteins)/II. Some of these effects may be exerted by its antioxidative potency.
MT-3 is able to alter the Tg2576 phenotype in several aspects such as mortality and behavior in a gender-dependent manner.
ZnMt3 in cultured astrocytes may be a normal component of c-Abl (show ABL1 Proteins) activation in EGF receptor (show EGFR Proteins) signaling
the level of the leptin receptor (show LEPR Proteins) in the hypothalamus of metallothionein-3-null mice was significantly reduced
Metallothionein-III null mice show attenuation of cadmium-induced severe testicular toxicity, suggesting that lack of MT-III contributes to protection of testis from cadmium.
Expression of MT-1a (show MT1A Proteins), MT-2b and MT-3 were significantly higher in high zinc fed pigs.
heavy metal binding protein\; acts as an inhibitor of neurite sprouting and deficiency may play a role in Alzheimer's disease
, growth inhibitory factor
, metallothionein 3 (growth inhibitory factor (neurotrophic))
, metallothionein III
, neurite growth inhibitory factor
, metallothionein 3
, neuronal growth inhibitory factor