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Chicken Polyclonal RIMS2 Primary Antibody for ICC, IHC - ABIN1742308
Gebhart, Juhasz-Vedres, Zuccotti, Brandt, Engel, Trockenbacher, Kaur, Obermair, Knipper, Koschak, Striessnig: Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule. in Molecular and cellular neurosciences 2010
Show all 13 Pubmed References
Human Polyclonal RIMS2 Primary Antibody for IHC, ELISA - ABIN1003091
Wang, Sugita, Sudhof: The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. in The Journal of biological chemistry 2000
Show all 3 Pubmed References
Rat (Rattus) Polyclonal RIMS2 Primary Antibody for IP, IHC - ABIN1742309
Regus-Leidig, Specht, Tom Dieck, Brandstätter: Stability of active zone components at the photoreceptor ribbon complex. in Molecular vision 2010
Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha (show RIMS1 Antibodies) for the CaV2.1 (show CACNA1A Antibodies) variant containing the region encoded by exons 44 and 47.
Here, we report that, like Rab3A (show RAB3A Antibodies), RIM (show RBBP8 Antibodies) and Munc13 (show UNC13B Antibodies) are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 (show CACNA1D Antibodies) gating kinetics in immature cochlear inner hair cells.
Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia.
tick-borne encephalitis virus -NS5 (show RAF1 Antibodies) has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble (show SCRIB Antibodies), whereas DENV-NS5 (show RAF1 Antibodies) binds primarily to the tight junction protein (show OCLN Antibodies) zonula occludens-1 (ZO-1 (show TJP1 Antibodies))
The function of RIM1 (show RIMS1 Antibodies)/2 at rod ribbons is to enhance Cav1.4 (show CACNA1F Antibodies) channel activity, possibly through direct or indirect modulation of the channel.
RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 (show CACNA1D Antibodies) Ca(2 (show CA2 Antibodies)+) channels at inner hair cell presynaptic active zones and are required for normal hearing.
Experiments with single Rim 1 (show RIMS1 Antibodies)/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim (show RIMS1 Antibodies) genes in vesicle priming/docking
Data suggest that RIM1 (show RIMS1 Antibodies)/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2 (show CA2 Antibodies))+ channel density and vesicle docking at the active zone.
Rim2alpha determines docking and priming states in insulin (show INS Antibodies) granule exocytosis depending on its interacting partner, Rab3A (show RAB3A Antibodies) or Munc13-1 (show UNC13A Antibodies), respectively.
Alternative splicing in the Rab (show HRB Antibodies)-binding domain of Rim2 (show AP3B1 Antibodies) regulates Rab3A (show RAB3A Antibodies) binding activity.
These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2 (show CA2 Antibodies)+)-triggering of exocytosis.
Cyclic AMP (show TMPRSS5 Antibodies) rescue of priming defects caused by Munc13-1 (show UNC13A Antibodies) deficiency signaling pathways requires downstream Munc13-1 (show UNC13A Antibodies)-Rim2 (show AP3B1 Antibodies) interaction.
synaptic protein important for normal neurotransmitter release\; binds Rab3a
regulating synaptic membrane exocytosis 2
, RAB3 interacting protein 3
, RIM 2
, non-small cell lung cancer RimL3a protein
, non-small cell lung cancer RimL3c protein
, nuclear protein
, rab-3-interacting molecule 2
, rab-3-interacting protein 3
, rab3-interacting molecule 2
, regulating synaptic membrane exocytosis protein 2
, Rab3 interacting protein 1
, Rab3 interacting protein 2
, rab-3-interacting protein 2
, rab3-interacting protein 2
, synaptic exocytosis regulator 2
, synaptotagmin 3, related sequence