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Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.
, PtdIns synthase
, phosphatidylinositol synthase
, CDP-diacylglycerol-inositol 3-phosphatidyltransferase
, ptdIns synthase
, CDP-diacylglycerol--inositol 3-phosphatidyltransferase