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Human Polyclonal PI4K2B Primary Antibody for IHC (p), ELISA - ABIN544188
Balla, Tuymetova, Barshishat, Geiszt, Balla: Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. in The Journal of biological chemistry 2002
Show all 3 Pubmed References
Human Polyclonal PI4K2B Primary Antibody for IHC (p), ELISA - ABIN544187
Mora, Durham, Smith, Russo, Jeromin, Pessin: NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway. in The Journal of biological chemistry 2002
Show all 3 Pubmed References
RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites.
Here two crystal structures are presented: the structure of human PIK42A and the structure of PIK42B containing a nucleoside analogue.
Results provide evidence that type II PtdIns 4-kinase b was indeed recruited to CD4- p56lck complex upon CD4 receptor cross linking, suggests a mechanism for its association and a role for it in CD4-mediated intracellular calcium release.
Canonical tyrosine residues mutation in FcepsilonRIgamma ITAM (Y65 and Y76) reveals that these two tyrosine residues in gamma subunit are required for its interaction with type II PtdIns 4-kinases.
type II PtdIns 4-kinase beta is a key component in early T cell activation signaling cascades
PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha.
There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded.
Type II PtdIns 4-kinase beta interacts with TCR-CD3 zeta chain. The C-terminal ITAM is critical for enzyme docking on the zeta chain. The association is tyrosyl phosphorylation dependent. Mutation of Y-151 & Y-142 disrupts interaction of the 2 proteins.
UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P.
LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells.
PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1.
PI4-kinase type 2beta (PI4K2beta) is identified as a regulator of the trans-Golgi network (TGN)/endosomal sorting and Wnt signaling. PI4K2beta and AP-1 interact directly and are required for efficient sorting between endosomes and the TGN.
Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002
phosphatidylinositol 4-kinase type 2-beta
, phosphatidylinositol 4-kinase type II-beta
, phosphatidylinositol 4-kinase type 2 beta
, phosphatidylinositol 4-kinase type 2-beta-like
, phosphatidylinositol 4-kinase type-II beta
, type II phosphatidylinositol 4-kinase beta
, phosphatidylinositol 4-kinase II beta
, pi4kII beta