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These results suggest direct roles for p38 MAPK and SAC1 in transmitting growth signals to the secretory machinery.
Sac1 executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles
the component proteins of the machinery, OSBP, VAP, SAC1, and PITPNB, are all essential host factors for AiV replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP/OSBP/SAC1 with the AiV proteins and with ACBD3.
results demonstrate that Sac1 expression in either the ER or Golgi apparatus has a minimal impact on the PI-4P that regulates OSBP activity or recruitment to contact sites
data suggest a model in which the 14-3-3 protein mediates SAC1 traffic from the ER through direct interaction with a sorting signal and COPII
the enzymatic function of hSAC1 provides a switch for accessibility of the COPI interaction motif
membrane lipid phosphatase with activity toward phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate substrates
phosphatidylinositide phosphatase SAC1
, suppressor of actin mutations 1-like protein
, polyphosphatidylinositol phosphatase
, suppressor of actin 1