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These results suggest direct roles for p38 MAPK (show MAPK14 Proteins) and SAC1 in transmitting growth signals to the secretory machinery.
Sac1 executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles
the component proteins of the machinery, OSBP (show OSBP Proteins), VAP (show F10 Proteins), SAC1, and PITPNB (show PITPNB Proteins), are all essential host factors for AiV (show ANXA4 Proteins) replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP (show F10 Proteins)/OSBP (show OSBP Proteins)/SAC1 with the AiV (show ANXA4 Proteins) proteins and with ACBD3 (show Acbd3 Proteins).
results demonstrate that Sac1 expression in either the ER or Golgi apparatus has a minimal impact on the PI-4P that regulates OSBP (show OSBP Proteins) activity or recruitment to contact sites
data suggest a model in which the 14-3-3 protein (show YWHAE Proteins) mediates SAC1 traffic from the ER through direct interaction with a sorting signal and COPII
membrane lipid phosphatase with activity toward phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate substrates
phosphatidylinositide phosphatase SAC1
, suppressor of actin mutations 1-like protein
, polyphosphatidylinositol phosphatase
, suppressor of actin 1